| Perfusion MR imaging and proton MR spectroscopic imaging in differentiating necrotizing cerebritis from glioblastoma multiforme. | |
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MedLine Citation:
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PMID: 17275620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a lesion with the magnetic resonance imaging (MRI) characteristics of a glioblastoma mutiforme and demonstrate how perfusion MRI and proton MR spectroscopic imaging can be used to differentiate necrotizing cerebritis from what appeared to be a high-grade glioma. A 43-year-old woman presented to her physician complaining of progressive visual disturbance and headache for several weeks. Conventional MRI demonstrated a parietal peripherally enhancing mass with central necrosis and moderate to severe surrounding T2 hyperintensity, suggesting an infiltrating high-grade glioma. However, advanced imaging, including dynamic susceptibility contrast MRI (DSC MRI) and magnetic resonance spectroscopic imaging (MRSI), suggested a nonneoplastic lesion. The DSC MRI data demonstrated no hyperperfusion within the lesion and surrounding T2 signal abnormality, and the MRSI data showed overall decrease in metabolites in this region, except for lactate. Because of the aggressive appearance to the lesion and the patients' worsening symptoms, a biopsy was performed. The pathologic diagnosis was necrotizing cerebritis. After the commencement of steroid therapy, imaging findings and patient symptoms improved. This report will review the utility of advanced imaging for differentiating inflammatory from neoplastic appearing lesions on conventional imaging. |
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Authors:
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Gabriel Pivawer; Meng Law; David Zagzag |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-11-20 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 25 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-05 Completed Date: 2007-04-03 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 238-43 Citation Subset: IM |
Affiliation:
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Department of Radiology, NYU Medical Center, New York, NY 10016, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Neoplasms / diagnosis Contrast Media Diagnosis, Differential Encephalitis / diagnosis* Female Gadolinium DTPA / diagnostic use Glioblastoma / diagnosis Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging / methods* Magnetic Resonance Spectroscopy / methods* Necrosis |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA111996-01A1/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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