| Perfusion MR imaging of extracranial tumor angiogenesis. | |
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MedLine Citation:
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PMID: 15057172 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic contrast-enhanced MRI (DCE-MRI) using small molecular weight gadolinium chelates enables noninvasive imaging characterization of tissue vascularity. Depending on the technique used, data reflecting tissue perfusion (blood flow, blood volume, mean transit time), microvessel permeability surface area product, and extracellular leakage space can be obtained. Insights into these physiological processes can be obtained from inspection of kinetic enhancement curves or by the application of complex compartmental modeling techniques. Combining morphologic and kinetic features can increase the accuracy of clinical diagnoses. Potential clinical applications include screening for malignant disease, lesion characterization, monitoring lesion response to treatment, and assessment of residual disease. Newer applications include prognostication, pharmacodynamic assessments of antivascular anticancer drugs, and predicting efficacy of treatment. For dynamic MRI to enter into widespread clinical practice, it will be necessary to develop standardized approaches to measurement and robust analysis approaches. |
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Authors:
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Anwar R Padhani; Andy Dzik-Jurasz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Topics in magnetic resonance imaging : TMRI Volume: 15 ISSN: 0899-3459 ISO Abbreviation: Top Magn Reson Imaging Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-04-01 Completed Date: 2004-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913523 Medline TA: Top Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 41-57 Citation Subset: IM |
Affiliation:
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*Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex, UK. anwar.padhani@paulstrickland-scannercentre.co.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Blood Volume Contrast Media Drug Screening Assays, Antitumor Gadolinium / diagnostic use Humans Magnetic Resonance Angiography Magnetic Resonance Imaging* / methods Neoplasms / blood supply*, drug therapy Neovascularization, Pathologic / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7440-54-2/Gadolinium |
| Comments/Corrections | |
Erratum In:
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Top Magn Reson Imaging. 2004 Apr;15(2):67 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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