| Perfusion Computed Tomography Findings of Autoimmune Pancreatitis. | |
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MedLine Citation:
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PMID: 21705954 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES:: The aim of this study was to clarify the pancreatic blood perfusion in patients with autoimmune pancreatitis (AIP) and the changes after steroid treatment. METHODS:: Perfusion computed tomography was performed in 11 patients with AIP and 12 control subjects. Pancreatic volumetric blood flow (FV), volume of distribution (VD), and blood transit time τ were determined from a single-compartment kinetic model. Nine patients with AIP were reexamined by perfusion computed tomography after corticosteroid administration. RESULTS:: The pancreatic FV values of the 11 patients with AIP (82.7/min) were significantly lower than those of control subjects (163.5/min, P = 0.0006). On the other hand, the pancreatic VD and τ values were not significantly different between AIP and normal. After steroid treatment, the FV values of 9 reexamined patients with AIP (76.2/min) were significantly elevated (109.8/min, P = 0.0391). However, the changes of the values after the treatment differed in degree among individuals. The values of 4 patients were dramatically elevated to greater than 100/min, whereas those of 4 other patients did not improve well. The value of the remaining patient whose initial FV value was normal (168.09/min) did not change after the treatment. CONCLUSIONS:: Pancreatic volumetric perfusion was attenuated in AIP patients. The perfusion was improved after the steroid treatment. |
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Authors:
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Morihisa Hirota; Masashi Tsuda; Yoshihisa Tsuji; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Shin Hamada; Jun Unno; Hiromichi Ito; Hiroyuki Ariga; Tsutomu Chiba; Atsushi Masamune; Kennichi Satoh; Tooru Shimosegawa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-23 |
Journal Detail:
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Title: Pancreas Volume: - ISSN: 1536-4828 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Division of Gastroenterology, and †Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai City, Miyagi; and ‡Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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