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Perfusion Computed Tomography Findings of Autoimmune Pancreatitis.
MedLine Citation:
PMID:  21705954     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: The aim of this study was to clarify the pancreatic blood perfusion in patients with autoimmune pancreatitis (AIP) and the changes after steroid treatment. METHODS:: Perfusion computed tomography was performed in 11 patients with AIP and 12 control subjects. Pancreatic volumetric blood flow (FV), volume of distribution (VD), and blood transit time τ were determined from a single-compartment kinetic model. Nine patients with AIP were reexamined by perfusion computed tomography after corticosteroid administration. RESULTS:: The pancreatic FV values of the 11 patients with AIP (82.7/min) were significantly lower than those of control subjects (163.5/min, P = 0.0006). On the other hand, the pancreatic VD and τ values were not significantly different between AIP and normal. After steroid treatment, the FV values of 9 reexamined patients with AIP (76.2/min) were significantly elevated (109.8/min, P = 0.0391). However, the changes of the values after the treatment differed in degree among individuals. The values of 4 patients were dramatically elevated to greater than 100/min, whereas those of 4 other patients did not improve well. The value of the remaining patient whose initial FV value was normal (168.09/min) did not change after the treatment. CONCLUSIONS:: Pancreatic volumetric perfusion was attenuated in AIP patients. The perfusion was improved after the steroid treatment.
Morihisa Hirota; Masashi Tsuda; Yoshihisa Tsuji; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Shin Hamada; Jun Unno; Hiromichi Ito; Hiroyuki Ariga; Tsutomu Chiba; Atsushi Masamune; Kennichi Satoh; Tooru Shimosegawa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-23
Journal Detail:
Title:  Pancreas     Volume:  -     ISSN:  1536-4828     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the *Division of Gastroenterology, and †Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai City, Miyagi; and ‡Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.
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