| Perfusion CT in hyperacute cerebral hemorrhage within 3 hours after symptom onset: is there an early perihemorrhagic penumbra? | |
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MedLine Citation:
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PMID: 19686316 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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INTRODUCTION: In the recent years numerous studies have been undertaken to study cerebral perfusion in the surrounding of intracerebral hemorrhage, addressing the question of whether there is a secondary ischemic damage. Most of these studies found a reduced perfusion adjacent to the hematoma. However, the meaning of these findings remains controversial. METHODS: We used perfusion computed tomography in 17 patients to study time to peak, cerebral blood flow, and cerebral blood volume as markers of the perihemorrhagic perfusion within 3 hours after symptom onset to search for an early difference between the extent of edema and reduced perfusion. RESULTS: All patients showed a significant reduction of all perfusion parameters in the perihemorrhagic area, while there was no difference between the latitude of the reduced perfusion and the edema. CONCLUSION: We did not find a difference between the extension of edema and that of restricted perfusion at a very early time point and therefore could not identify any tissue at risk of ischemia. Our findings suggest reduced perfusion and edema to have a common cause rather than presupposing one another. |
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Authors:
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Christian Herweh; Eric Jüttler; Peter D Schellinger; Ernst Klotz; Peter Schramm |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 20 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: 350-3 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 by the American Society of Neuroimaging. |
Affiliation:
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Department of Neuroradiology, Heidelberg Medical School, University of Heidelberg, Heidelberg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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