| Perfusion CT and US of colorectal cancer liver metastases: a correlative study of two dynamic imaging modalities. | |
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MedLine Citation:
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PMID: 20800954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate the correlation between dynamic-contrast-enhanced computed tomography (DCE-CT) and first-pass dynamic-contrast-enhanced ultrasound (DCE-US) of normal appearing liver parenchyma and of colorectal cancer liver metastases. Thirty patients with hepatic metastases from colorectal cancer underwent DCE-CT and DCE-US. To obtain DCE-US reproducibility measurements, double contrast-passages (2 × 2.4 mL SonoVue intravenous) were acquired. From several DCE-US-derived perfusion indices, the slope-value scored best with a reproducibility concordance correlation coefficient ranging from 0.75-0.93 and overall highest correlation to DCE-CT-derived variables (r = 0.52 to 0.73). The DCE-US-based tumor-to-liver perfusion gradient also showed a low test-retest variability and moderately correlated to DCE-CT (concordance correlation coefficient 0.87-0.92; r = 0.57 to 0.59). To conclude, DCE-US-based slope-value and tumor-to-liver perfusion gradient correlate best with DCE-CT perfusion values. However, both techniques cannot be used interchangeably. DCE-US should be restricted for studies in which a considerable change in perfusion is expected and for patients with a relatively high tumor blood flow at baseline. |
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Authors:
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Martijn R Meijerink; Jan Hein T M van Waesberghe; Cors van Schaik; Epie Boven; Astrid A M van der Veldt; Petrousjka van den Tol; Sybren Meijer; Cornelis van Kuijk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 36 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1626-36 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands. mr.meijerink@vumc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Colorectal Neoplasms / pathology* Contrast Media / diagnostic use Female Humans Iohexol / analogs & derivatives, diagnostic use Liver / radiography*, ultrasonography* Liver Neoplasms / blood supply, diagnosis*, secondary* Male Middle Aged Perfusion Imaging / methods Phospholipids / diagnostic use Radiographic Image Enhancement / methods Reproducibility of Results Sulfur Hexafluoride / diagnostic use Tomography, Spiral Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Phospholipids; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride; 66108-95-0/Iohexol; 73334-07-3/iopromide |
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