Document Detail

Performing functional magnetic resonance imaging in patients with Parkinson's disease treated with deep brain stimulation.
MedLine Citation:
PMID:  16671094     Owner:  NLM     Status:  MEDLINE    
Deep brain stimulation (DBS) is a relatively novel treatment in advanced Parkinson's disease (PD). Functional magnetic resonance imaging (fMRI) is a useful technique for examining the effects of DBS both within the basal ganglia and its cortical connectivity. There are technical difficulties in imaging patients with PD, and the DBS itself can generate image artifacts. We describe aspects related to optimizing the fMRI acquisition parameters in patients with DBS and the results of sensorimotor activation tasks performed by four PD patients during hand, foot, and tongue movements, both before and after DBS implant. Provided that all safety conditions are followed, it is possible to perform fMRI in patients with PD and DBS. The standard DBS surgical procedure has to be slightly modified in order to reduce image artifacts. The event-related design provided increased power to detect sensorimotor cortex and basal ganglia activation.
Paula R Arantes; Ellison F Cardoso; Maria A Barreiros; Manoel J Teixeira; Márcia R Gonçalves; Egberto R Barbosa; Sukhi Shergill Sukwinder; Claudia C Leite; Edson Amaro
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  21     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-30     Completed Date:  2007-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1154-62     Citation Subset:  IM    
Copyright Information:
(c) 2006 Movement Disorder Society
Department of Radiology, University of São Paulo Medical School, São Paulo, Brazil.
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MeSH Terms
Brain / pathology
Deep Brain Stimulation*
Disease Progression
Functional Laterality
Magnetic Resonance Imaging / methods*
Middle Aged
Motor Activity
Oxygen / blood
Parkinson Disease / physiopathology*,  therapy*
Treatment Outcome
Reg. No./Substance:

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