Document Detail


Performance tests of a novel coaxial tube catheter in an in vitro model of intracranial cell delivery.
MedLine Citation:
PMID:  21231825     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
We have tested prototypes of a novel coaxial tube catheter in an in vitro gel model of cell delivery into the brain. Devices 1.6 and 2.0 mm outer diameter were used to deliver PC 12 cells (concentration = 10⁶ cells ml⁻¹ at 1 μl min⁻¹ into a 5 ml sandwich of collagen and 0.1% agarose, with and without follow-on infusions of nerve growth factor (NGF). Post-infusion microscopic imaging (40X) at the infusion sites was then carried out over 7-day periods. The results showed that under these experimental conditions, it was possible to use these catheters to deliver cells without either leakage of trapped air into the gel or reflux of the cell suspension along the catheter insertion track. Differentiation of the NGF-treated cells was observed.
Authors:
S J Panse; H L Fillmore; Z J Chen; G T Gillies; W C Broaddus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical engineering & technology     Volume:  35     ISSN:  1464-522X     ISO Abbreviation:  J Med Eng Technol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702125     Medline TA:  J Med Eng Technol     Country:  England    
Other Details:
Languages:  eng     Pagination:  77-86     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Virginia Commonwealth University, PO Box 980631, Richmond, Virginia 23298-0631, USA.
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