| Performance of schizophrenic patients in the Stroop Color Word Test and electrodermal responsiveness after acute administration of cannabidiol (CBD). | |
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MedLine Citation:
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PMID: 20339735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The last decade has seen increasing evidence of dysfunctions in the endogenous cannabinoid system in schizophrenia and of its relationship with the typical cognitive impairment of the disorder. Studies in animal models, healthy volunteers, and psychotic patients clearly suggest an antipsychotic-like effect of cannabidiol. This study investigated the effects of cannabidiol on selective attention in 28 schizophrenic patients using the Stroop Color Word Test and on these patients' electrodermal responsiveness to auditive stimuli. METHOD: The subjects attended two experimental sessions, the first one without the administration of drugs. In the second session the subjects were divided into three groups that received either a single dose of cannabidiol 300 mg or cannabidiol 600 mg or placebo. RESULTS: The three groups did not differ significantly with respect to electrodermal measures in the two experimental sessions. When the first and second sessions were compared improved performance was found in all three groups, with patients who received placebo and cannabidiol 300 mg performing better than those who received cannabidiol 600 mg. CONCLUSION: The single, acute administration of cannabidiol seems to have no beneficial effects on the performance of schizophrenic patients in the Stroop Color Word Test, although the hypothesis that chronic administration may lead to improvement cannot be disregarded. |
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Authors:
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Jaime E C Hallak; João Paulo Machado-de-Sousa; José Alexandre S Crippa; Rafael Faria Sanches; Clarissa Trzesniak; Cristiano Chaves; Sandra Aparecida Bernardo; Simone Cecílio Regalo; Antonio Waldo Zuardi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Revista brasileira de psiquiatria (São Paulo, Brazil : 1999) Volume: 32 ISSN: 1516-4446 ISO Abbreviation: Rev Bras Psiquiatr Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100895975 Medline TA: Rev Bras Psiquiatr Country: Brazil |
Other Details:
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Languages: eng Pagination: 56-61 Citation Subset: IM |
Affiliation:
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University Hospital of the Ribeirão Preto Medical School, Department of Neuroscience and Behavior, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. jhallak@fmrp.usp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Antipsychotic Agents / administration & dosage* Cannabidiol / administration & dosage* Cognition / drug effects, physiology Dose-Response Relationship, Drug Female Galvanic Skin Response* Humans Male Psychotic Disorders / drug therapy* Schizophrenia / physiopathology Schizophrenic Psychology* Stroop Test* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 13956-29-1/Cannabidiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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