Document Detail

Performance of osteopontin in the diagnosis of malignant pleural mesothelioma: a meta-analysis.
MedLine Citation:
PMID:  24995085     Owner:  NLM     Status:  PubMed-not-MEDLINE    
It is reported that osteopontin has shown promising diagnostic value for malignant pleural mesothelioma (MPM), this meta-analysis aimed to establish the overall diagnostic accuracy of the osteopontin measurement for diagnosing MPM. Based on a systematic review of English language studies, the sensitivity, specificity and other measures of accuracy of osteopontin in the diagnosis of MPM were pooled using random-effects model. Summary receiver operating characteristic curves were used to summarize overall test performance. Seven publications met our inclusion criteria, the pooled sensitivity was 0.57 (95%CI: 0.52-0.61), specificity was 0.81, 95%CI: 0.79-0.84). The PLR was 3.78 (95%CI: 2.23-6.41), the NLR was 0.51 (95%CI: 0.38-0.67) and the DOR was 9.04 (95%CI: 5.28-15.48), the area under the summary receiver operating characteristic curve was 0.80. Our data suggest that osteopontin is likely to be a useful diagnostic marker for MPM, considering for the limited studies and patients included, larger studies are needed to confirm these findings.
Hui Lin; Yong-Chun Shen; Hong-Yu Long; Hao Wang; Ze-Yu Luo; Zi-Xuan Wei; Shi-Qi Hu; Fu-Qiang Wen
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Publication Detail:
Type:  Journal Article     Date:  2014-05-15
Journal Detail:
Title:  International journal of clinical and experimental medicine     Volume:  7     ISSN:  1940-5901     ISO Abbreviation:  Int J Clin Exp Med     Publication Date:  2014  
Date Detail:
Created Date:  2014-07-04     Completed Date:  2014-07-04     Revised Date:  2014-07-07    
Medline Journal Info:
Nlm Unique ID:  101471010     Medline TA:  Int J Clin Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1289-96     Citation Subset:  -    
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