| Performance of mouse lines divergently selected for heat loss when exposed to different environmental temperatures. I. Reproductive performance, pup survival, and metabolic hormones. | |
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MedLine Citation:
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PMID: 15484937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mouse populations differing in metabolic rate have been developed through selection for high (MH) and low (ML) heat loss, along with the unselected controls (MC). Objectives of the study were to compare the MH, ML, and MC lines for reproductive performance, pup survival, and metabolic hormones when reared at 12, 22, and 31 degrees C, and to search for line x environment interactions. Conception and litter size were recorded on the parent generation mice introduced to the environments at 11 wk of age and bred after a 3-wk acclimatization period. Survival of pups (preweaning to 3 wk; postweaning from 3 to 9 wk of age) was measured with continuous exposure in the designated environment from birth to the time of measurement. Corticosterone, triiodothyronine (T3), and thyroxine (T4) serum concentrations were measured on the parent generation after producing litters and on the pup generation at 9 wk. No line x environment interaction was detected for conception rate, preweaning mortality, postweaning survival, pup weaning weight, or body temperature. There were no differences in conception rate among lines and environments. Environments affected survival of pups, but there were no line differences. Rectal body temperatures were greater for MH than ML mice, and MC mice were intermediate; body temperature of mice did not differ among the environments. Lines differed significantly in litter size only in the 22 degrees C environment. No significant line differences were found for serum corticosterone or serum T3 or T4. Line x environment interaction was detected only for litter size and for serum corticosterone concentration in dams. Contrary to the other two lines, ML dam performance relative to MH and MC was not affected negatively by either of the thermal environments. Results from this study do not raise concern that selection to decrease maintenance requirements will produce livestock with any greater liability to cope and perform under an array of environmental temperatures. |
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Authors:
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P M Kgwatalala; J L DeRoin; M K Nielsen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of animal science Volume: 82 ISSN: 0021-8812 ISO Abbreviation: J. Anim. Sci. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-15 Completed Date: 2005-03-17 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8003002 Medline TA: J Anim Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2876-83 Citation Subset: IM |
Affiliation:
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Department of Animal Science, University of Nebraska, Lincoln 68583-0908, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / genetics*, physiology Corticosterone / blood Environment Female Genotype Litter Size / genetics*, physiology Male Mice Mice, Inbred Strains / genetics*, growth & development*, metabolism Reproduction / genetics*, physiology Selection, Genetic* Survival Analysis Temperature Thyroxine / blood Triiodothyronine / blood |
| Chemical | |
Reg. No./Substance:
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50-22-6/Corticosterone; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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