Document Detail

Performance of the isolated, ejecting heart: effects of aortic impedance and exogenous substrates.
MedLine Citation:
PMID:  1945764     Owner:  NLM     Status:  MEDLINE    
The workload of the isolated, left-ventricular ejecting heart (i.e. working heart) is determined by the left atrial filling pressure and the afterload imposed on the left ventricular outflow tract. In addition to the level of end-diastolic aortic pressure, afterload is highly determined by the aortic impedance. For the isolated, ejecting heart optimum matching of the left ventricle to its afterload requires the highest possible similarity between the impedance of the artificial aortic conduit and the natural aortic impedance. The present study shows that the haemodynamic performance of the ejecting rat heart preparation can be affected by the impedance of the aortic conduit. A proper choice of substrates in the perfusion fluid further improves the performance of the heart in the artificial set-up. The present paper also provides guidelines with respect to the design of the aortic cannula and compliance chamber. The occurrence of turbulence, which is related to the Bernoulli pressure drop, is a major determinant of the impedance of the aortic conduit. This effect is used to simulate the natural resistance component of the aortic impedance. Further, the applicability of the perfusion model can be extended by the so-called assisted-mode perfusion, which allows automatic adjustment from antegrade to retrograde perfusion if the heart is not able to generate sufficient pumping power to provide its own coronary perfusion.
M Van Bilsen; L H Snoeckx; T Arts; G J Van der Vusse; R S Reneman
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  419     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-11-29     Completed Date:  1991-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
Department of Physiology, University of Limburg, Maastricht, The Netherlands.
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MeSH Terms
Aorta / physiology*
Glucose / pharmacology*
Heart / drug effects,  physiology*
Myocardial Contraction*
Pyruvates / pharmacology*
Pyruvic Acid
Rats, Inbred Lew
Vascular Resistance*
Reg. No./Substance:
0/Pyruvates; 127-17-3/Pyruvic Acid; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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