Document Detail


Performance-enhancing and thermoregulatory effects of intracerebroventricular dopamine in running rats.
MedLine Citation:
PMID:  19549536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the role of central dopamine on metabolic rate, heat balance and running performance, 2.0 microL of 5 x 10(-3)M dopamine solution (DA) or 0.15M NaCl (SAL) was intracerebroventricularly injected in Wistar rats 1 min before running on a motor-driven treadmill, according to a graded exercise protocol, until fatigue. Oxygen consumption (VO(2)) and body temperature (T(b)) were recorded at rest, during exercise, and after 30 min of recovery. DA induced a marked increase in workload (approximately 45%, p<0.05). At fatigue point, DA-injected rats attained approximately 29% higher maximum oxygen consumption (VO(2max)) and approximately 0.75 degrees C higher T(b) than SAL-injected rats. Despite the higher VO(2max) and T(b) attained during exercise, DA-treated rats reached VO(2) basal values within the same recovery period and dissipated heat approximately 33% faster than SAL-treated rats (p<0.05). The mechanical efficiency loss rate was approximately 40% lower in DA than in SAL-treated rats (p<0.05), however, the heat storage was approximately 35% higher in the DA group (p<0.05). Our results demonstrate that increased DA availability in the brain has a performance-enhancing effect, which is mediated by improvements in the tolerance to heat storage and increases in the metabolic rate induced by graded exercise. These data provide further evidence that central activation of dopaminergic pathways plays an important role in exercise performance.
Authors:
Cláudio H Balthazar; Laura H R Leite; Alex G Rodrigues; Cândido C Coimbra
Related Documents :
8364166 - Inhibition of rat mammary tumorigenesis by voluntary exercise.
20726846 - The effects of early exercise on brain damage and recovery after focal cerebral infarct...
20616226 - Voluntary wheel running exercise and dietary lactose concomitantly reduce proportion of...
11049216 - Iron distribution in different tissues in rats following exercise.
22083536 - Comparison of the acute impact of maximal arm and leg aerobic exercise on arterial stif...
12489596 - A historical overview of enhanced external counterpulsation.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-21
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  93     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-9     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
Animals
Body Temperature Regulation / drug effects*
Brain / metabolism
Dopamine / administration & dosage,  metabolism,  pharmacology*
Energy Metabolism / drug effects
Hippocampus / drug effects,  metabolism
Hypothalamus / drug effects,  metabolism
Injections, Intraventricular
Male
Oxygen Consumption / drug effects,  physiology
Preoptic Area / drug effects,  metabolism
Psychomotor Performance / drug effects*
Rats
Rats, Wistar
Running / physiology*
Chemical
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cocaine and automaintained responding in pigeons: rate-reducing effects and tolerance thereto with d...
Next Document:  Response surface optimization of polysaccharides extraction from liriope roots and its modulatory ef...