| Performance characteristics of scintigraphic colon transit measurement in health and irritable bowel syndrome and relationship to bowel functions. | |
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MedLine Citation:
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PMID: 20025675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The inter- and intra-subject variations of scintigraphy, which are used to identify colonic transit disturbances in irritable bowel syndrome (IBS), are unclear. The relationship between colonic transit and bowel functions is incompletely understood. To assess inter- and intra-subject variations of scintigraphic colonic transit measurements in 86 IBS patients and 17 healthy subjects and to quantify the relationship between colonic transit and bowel symptoms in 147 IBS patients and 46 healthy subjects. METHODS: Data from participants with multiple colonic transit measurements were analysed. Primary end points were colonic filling at 6 h (CF6h) and geometric center (GC) at 24 and 48 h for colonic transit. Bowel functions were assessed by daily stool diaries. KEY RESULTS: Inter- and intra-subject variations were greater for small intestinal than colonic transit. Overall, inter- and intra-subject variations were relatively narrow for colonic transit (both GC24h and GC48h, with lower COV at 48 h); there was little intra-subject variation in health and IBS-constipation over a period of <or=3 weeks and over 2.0 years (median, range 0.1, 11.0 years). Significant intra-individual differences in GC24h were observed only in IBS-D patients. Colonic transit was significantly associated with stool form (accounting for 19-27% of the variance), frequency (19%), and ease of stool passage (12%). CONCLUSIONS & INFERENCES: Despite inter-subject variation in scintigraphic colonic transit results, the intra-subject measurements are reproducible over time in healthy volunteers and patients with IBS; significant changes in colonic transit at 24 h were observed only in IBS-D. Colonic transit is associated with stool form, frequency and ease of passage. |
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Authors:
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A Deiteren; M Camilleri; A E Bharucha; D Burton; S McKinzie; A S Rao; A R Zinsmeister |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-12-18 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 22 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-09 Completed Date: 2010-06-28 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 415-23, e95 Citation Subset: IM |
Affiliation:
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Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Colon
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physiopathology*,
radionuclide imaging Constipation / physiopathology*, radionuclide imaging Defecation / physiology* Female Gastrointestinal Transit / physiology* Humans Irritable Bowel Syndrome / physiopathology*, radionuclide imaging Male Reference Values Regression Analysis Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK-54681/DK/NIDDK NIH HHS; R01 DK054681-08/DK/NIDDK NIH HHS; R01 DK078924-04/DK/NIDDK NIH HHS |
| Comments/Corrections | |
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