Document Detail


Performance characteristics of the measurement of gastric volume using single photon emission computed tomography.
MedLine Citation:
PMID:  21210894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A non-invasive single photon emission computed tomography (SPECT) method was developed and validated to measure gastric volumes (GV). The natural variation in gastric volume responses and performance characteristics of SPECT imaging are unclear.
METHODS: The primary aim of this study was to assess the performance characteristics of SPECT imaging by estimating the inter-individual coefficients of variation (COV) in fasting and postprandial GV in 433 participants in prior research studies over the last decade, and the intra-individual COV in all volunteers who had undergone at least two studies. The secondary aim was to assess the relationship of gender, BMI and age on GV.
KEY RESULTS: The COV(INTER) for all subjects in the study (n = 433) was 32.6% fasting, 16.0% fed, and 19.0%Δ fed - fasting. The COV(INTRA) for 47 subjects with repeat estimates of gastric volume was 37.0% fasting, 17.6% fed, and 22.0%Δ fed - fasting. COV(INTRA) was stable over time interval from 2 to 60 months. There were no significant differences by gender or subgroups. Mean fed and gastric accommodation volumes were associated with age and BMI but the magnitude of variation attributable was <5%.
CONCLUSIONS & INFERENCES: COV(INTRA) and COV(INTER) of GV by SPECT are very similar, and there is a small effect of age and BMI. These data are important for planning future studies of GV and further validate SPECT for studies of gastric motility disorders and obesity.
Authors:
M Breen; M Camilleri; D Burton; A R Zinsmeister
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-06
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  23     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-05-31     Completed Date:  2011-10-11     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  308-15     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Body Mass Index
Fasting / physiology
Female
Gastrointestinal Motility / physiology*
Humans
Male
Middle Aged
Organ Size
Postprandial Period / physiology
Sex Factors
Stomach / anatomy & histology,  physiology*,  radionuclide imaging*
Tomography, Emission-Computed, Single-Photon / methods*
Grant Support
ID/Acronym/Agency:
1RC1-DK086182/DK/NIDDK NIH HHS; R01 DK067071/DK/NIDDK NIH HHS; R01 DK067071-07/DK/NIDDK NIH HHS; R01-DK079866/DK/NIDDK NIH HHS; R01-DK67071/DK/NIDDK NIH HHS
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