| Performance characteristics of the measurement of gastric volume using single photon emission computed tomography. | |
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MedLine Citation:
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PMID: 21210894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A non-invasive single photon emission computed tomography (SPECT) method was developed and validated to measure gastric volumes (GV). The natural variation in gastric volume responses and performance characteristics of SPECT imaging are unclear. METHODS: The primary aim of this study was to assess the performance characteristics of SPECT imaging by estimating the inter-individual coefficients of variation (COV) in fasting and postprandial GV in 433 participants in prior research studies over the last decade, and the intra-individual COV in all volunteers who had undergone at least two studies. The secondary aim was to assess the relationship of gender, BMI and age on GV. KEY RESULTS: The COV(INTER) for all subjects in the study (n = 433) was 32.6% fasting, 16.0% fed, and 19.0%Δ fed - fasting. The COV(INTRA) for 47 subjects with repeat estimates of gastric volume was 37.0% fasting, 17.6% fed, and 22.0%Δ fed - fasting. COV(INTRA) was stable over time interval from 2 to 60 months. There were no significant differences by gender or subgroups. Mean fed and gastric accommodation volumes were associated with age and BMI but the magnitude of variation attributable was <5%. CONCLUSIONS & INFERENCES: COV(INTRA) and COV(INTER) of GV by SPECT are very similar, and there is a small effect of age and BMI. These data are important for planning future studies of GV and further validate SPECT for studies of gastric motility disorders and obesity. |
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Authors:
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M Breen; M Camilleri; D Burton; A R Zinsmeister |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-06 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 23 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-05-31 Completed Date: 2011-10-11 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 308-15 Citation Subset: IM |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, MN 55905, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Body Mass Index Fasting / physiology Female Gastrointestinal Motility / physiology* Humans Male Middle Aged Organ Size Postprandial Period / physiology Sex Factors Stomach / anatomy & histology, physiology*, radionuclide imaging* Tomography, Emission-Computed, Single-Photon / methods* |
| Grant Support | |
ID/Acronym/Agency:
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1RC1-DK086182/DK/NIDDK NIH HHS; R01 DK067071/DK/NIDDK NIH HHS; R01 DK067071-07/DK/NIDDK NIH HHS; R01-DK079866/DK/NIDDK NIH HHS; R01-DK67071/DK/NIDDK NIH HHS |
| Comments/Corrections | |
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