Document Detail

Performance of cancer cluster Q-statistics for case-control residential histories.
MedLine Citation:
PMID:  23149326     Owner:  NLM     Status:  MEDLINE    
Few investigations of health event clustering have evaluated residential mobility, though causative exposures for chronic diseases such as cancer often occur long before diagnosis. Recently developed Q-statistics incorporate human mobility into disease cluster investigations by quantifying space- and time-dependent nearest neighbor relationships. Using residential histories from two cancer case-control studies, we created simulated clusters to examine Q-statistic performance. Results suggest the intersection of cases with significant clustering over their life course, Q(i), with cases who are constituents of significant local clusters at given times, Q(it), yielded the best performance, which improved with increasing cluster size. Upon comparison, a larger proportion of true positives were detected with Kulldorf's spatial scan method if the time of clustering was provided. We recommend using Q-statistics to identify when and where clustering may have occurred, followed by the scan method to localize the candidate clusters. Future work should investigate the generalizability of these findings.
Chantel D Sloan; Geoffrey M Jacquez; Carolyn M Gallagher; Mary H Ward; Ole Raaschou-Nielsen; Rikke Baastrup Nordsborg; Jaymie R Meliker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2012-09-24
Journal Detail:
Title:  Spatial and spatio-temporal epidemiology     Volume:  3     ISSN:  1877-5853     ISO Abbreviation:  Spat Spatiotemporal Epidemiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-04-12     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  101516571     Medline TA:  Spat Spatiotemporal Epidemiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  297-310     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Case-Control Studies*
Cluster Analysis*
Denmark / epidemiology
Geographic Information Systems
Models, Statistical
Neoplasms / epidemiology*
Population Dynamics* / statistics & numerical data
Spatial Analysis*
Time Factors
United States / epidemiology
Grant Support
5R44CA112743-03/CA/NCI NIH HHS; 5R44CA135818-03/CA/NCI NIH HHS; N01-PC-65064/PC/NCI NIH HHS; N01-PC-67008/PC/NCI NIH HHS; N01-PC-67009/PC/NCI NIH HHS; N01-PC-67010/PC/NCI NIH HHS; N02-PC-71105/PC/NCI NIH HHS; R03 CA125827/CA/NCI NIH HHS; R03 CA125827/CA/NCI NIH HHS; R21 ES015501/ES/NIEHS NIH HHS

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