Document Detail

Performance of biodegradable microcapsules of poly(butylene succinate), poly(butylene succinate-co-adipate) and poly(butylene terephthalate-co-adipate) as drug encapsulation systems.
MedLine Citation:
PMID:  21376545     Owner:  NLM     Status:  MEDLINE    
Poly(butylene succinate) (PBSu), poly(butylene succinate-co-adipate) (PBSA) and poly(butylene terephthalate-co-adipate) (PBTA) microcapsules were prepared by the double emulsion/solvent evaporation method. The effect of polymer and poly(vinyl alcohol) (PVA) concentration on the microcapsule morphologies, drug encapsulation efficiency (EE) and drug loading (DL) of bovine serum albumin (BSA) and all-trans retinoic acid (atRA) were all investigated. As a result, the sizes of PBSu, PBSA and PBTA microcapsules were increased significantly by varying polymer concentrations from 6 to 9%. atRA was encapsulated into the microcapsules with an high level of approximately 95% EE. The highest EE and DL of BSA were observed at 1% polymer concentration in values of 60 and 37%, respectively. 4% PVA was found as the optimum concentration and resulted in 75% EE and 14% DL of BSA. The BSA release from the capsules of PBSA was the longest, with 10% release in the first day and a steady release of 17% until the end of day 28. The release of atRA from PBSu microcapsules showed a zero-order profile for 2 weeks, keeping a steady release rate during 4 weeks with a 9% cumulative release. Similarly, the PBSA microcapsules showed a prolonged and a steady release of atRA during 6 weeks with 12% release. In the case of PBTA microcapsules, after a burst release of 10% in the first day, showed a parabolic release profile of atRA during 42 days, releasing 36% of atRA.
Cornelia Theresa Brunner; Erkan Türker Baran; Elisabete Duarte Pinho; Rui Luís Reis; Nuno Meleiro Neves
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-03
Journal Detail:
Title:  Colloids and surfaces. B, Biointerfaces     Volume:  84     ISSN:  1873-4367     ISO Abbreviation:  Colloids Surf B Biointerfaces     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-05     Revised Date:  2011-09-27    
Medline Journal Info:
Nlm Unique ID:  9315133     Medline TA:  Colloids Surf B Biointerfaces     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  498-507     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, S. Cláudio do Barco, 4806-909 Taipas, Guimarães, Portugal.
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MeSH Terms
Absorbable Implants*
Adipic Acids / chemistry*
Butylene Glycols / chemistry*
Delayed-Action Preparations*
Hydrophobic and Hydrophilic Interactions
Microscopy, Electron, Scanning
Molecular Structure
Particle Size
Polyesters / chemistry*
Polymers / chemistry*
Serum Albumin, Bovine / chemistry*,  pharmacology
Succinates / chemistry*
Tretinoin / chemistry*,  pharmacology
Reg. No./Substance:
0/Adipic Acids; 0/Butylene Glycols; 0/Capsules; 0/Delayed-Action Preparations; 0/Polyesters; 0/Polymers; 0/Serum Albumin, Bovine; 0/Succinates; 0/bionole; 0/poly(butylene adipate-co-butylene terephthalate); 0/poly(butylene succinate-co-butylene adipate); 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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