| Performance of biodegradable microcapsules of poly(butylene succinate), poly(butylene succinate-co-adipate) and poly(butylene terephthalate-co-adipate) as drug encapsulation systems. | |
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MedLine Citation:
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PMID: 21376545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(butylene succinate) (PBSu), poly(butylene succinate-co-adipate) (PBSA) and poly(butylene terephthalate-co-adipate) (PBTA) microcapsules were prepared by the double emulsion/solvent evaporation method. The effect of polymer and poly(vinyl alcohol) (PVA) concentration on the microcapsule morphologies, drug encapsulation efficiency (EE) and drug loading (DL) of bovine serum albumin (BSA) and all-trans retinoic acid (atRA) were all investigated. As a result, the sizes of PBSu, PBSA and PBTA microcapsules were increased significantly by varying polymer concentrations from 6 to 9%. atRA was encapsulated into the microcapsules with an high level of approximately 95% EE. The highest EE and DL of BSA were observed at 1% polymer concentration in values of 60 and 37%, respectively. 4% PVA was found as the optimum concentration and resulted in 75% EE and 14% DL of BSA. The BSA release from the capsules of PBSA was the longest, with 10% release in the first day and a steady release of 17% until the end of day 28. The release of atRA from PBSu microcapsules showed a zero-order profile for 2 weeks, keeping a steady release rate during 4 weeks with a 9% cumulative release. Similarly, the PBSA microcapsules showed a prolonged and a steady release of atRA during 6 weeks with 12% release. In the case of PBTA microcapsules, after a burst release of 10% in the first day, showed a parabolic release profile of atRA during 42 days, releasing 36% of atRA. |
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Authors:
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Cornelia Theresa Brunner; Erkan Türker Baran; Elisabete Duarte Pinho; Rui Luís Reis; Nuno Meleiro Neves |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-03 |
Journal Detail:
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Title: Colloids and surfaces. B, Biointerfaces Volume: 84 ISSN: 1873-4367 ISO Abbreviation: Colloids Surf B Biointerfaces Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-07-05 Revised Date: 2011-09-27 |
Medline Journal Info:
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Nlm Unique ID: 9315133 Medline TA: Colloids Surf B Biointerfaces Country: Netherlands |
Other Details:
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Languages: eng Pagination: 498-507 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, S. Cláudio do Barco, 4806-909 Taipas, Guimarães, Portugal. corneliabrunner@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants* Adipic Acids / chemistry* Animals Butylene Glycols / chemistry* Capsules* Cattle Delayed-Action Preparations* Hydrophobic and Hydrophilic Interactions Microscopy, Electron, Scanning Molecular Structure Particle Size Polyesters / chemistry* Polymers / chemistry* Serum Albumin, Bovine / chemistry*, pharmacology Succinates / chemistry* Tretinoin / chemistry*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adipic Acids; 0/Butylene Glycols; 0/Capsules; 0/Delayed-Action Preparations; 0/Polyesters; 0/Polymers; 0/Serum Albumin, Bovine; 0/Succinates; 0/bionole; 0/poly(butylene adipate-co-butylene terephthalate); 0/poly(butylene succinate-co-butylene adipate); 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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