Document Detail

Performance of acidified 14C-urea capsule breath test during pantoprazole and ranitidine treatment.
MedLine Citation:
PMID:  19486449     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Urea breath test (UBT) results could be false negative in patients taking antisecretory drugs. This effect would be prevented by citric acid administration during UBT. We prospectively investigated whether acidified 14C-urea capsule prevents false negative UBT results in patients taking antisecretory drugs and show interference with the duration of medications.
METHODS: Sixty Helicobacter pylori positive patients were included. Pantoprazole (40 mg/day) was given to 27 patients for 28 days and ranitidine (300 mg. o.d.) to 33 patients for 60 days. Urea breath tests were repeated on days 14 and 28 in both groups and on day 60 in the ranitidine group.
RESULTS: The baseline mean breath counts of two groups did not show any significant difference. Pantoprazole led to a significant decrease in mean breath counts on day 14 (P < 0.005). Six of 27 and 3 of 25 patients taking pantoprazole developed negative or equivocal UBT results on days 14 and 28, respectively. Two of 32, 2 of 32 and 3 of 21 patients taking ranitidine developed negative or equivocal UBT results on days 14, 28 and 60, respectively.
CONCLUSIONS: The use of acidified 14C-urea capsule did not prevent false negative UBT results in patients taking pantoprazole and ranitidine, and the duration of medication does not affect the test results.
Emel Oztürk; Zeki Yeşilova; Seyfettin Ilgan; Mehmet Ozgüven; Kemal Dağalp
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-04-13
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  24     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-10-28     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1248-51     Citation Subset:  IM    
Department of Nuclear Medicine, Ufuk University Medical School, Gülhane Military Medical Academy and Medical School, Ankara, Turkey.
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MeSH Terms
2-Pyridinylmethylsulfinylbenzimidazoles / adverse effects,  therapeutic use*
Breath Tests*
Carbon Radioisotopes
Citric Acid / diagnostic use*
False Negative Reactions
Helicobacter Infections / diagnosis,  drug therapy*,  microbiology
Helicobacter pylori / metabolism*
Predictive Value of Tests
Prospective Studies
Proton Pump Inhibitors / adverse effects,  therapeutic use*
Ranitidine / adverse effects,  therapeutic use*
Time Factors
Treatment Outcome
Urea / diagnostic use*
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Capsules; 0/Carbon Radioisotopes; 0/Proton Pump Inhibitors; 57-13-6/Urea; 66357-35-5/Ranitidine; 77-92-9/Citric Acid; D8TST4O562/pantoprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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