Document Detail

Performance on the Wisconsin card-sorting test and serum levels of glial cell line-derived neurotrophic factor in patients with major depressive disorder.
MedLine Citation:
PMID:  24436216     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Some evidence suggests that neurotrophic growth factor systems might be involved in the etiology of major depressive disorder (MDD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor-β family that plays a role in the development and function of the brain. This study aimed to test whether GDNF in serum was abnormal in MDD, and whether it was related to the cognitive impairment of MDD.
METHODS: Serum GDNF levels in MDD patients (n = 32) and normal controls (n = 32) were measured with the enzyme-linked immunosorbent assay method. All subjects were assessed for performance on the Wisconsin card-sorting test (WCST).
RESULTS: Performance on the WCST in MDD patients was significantly poorer than that in controls. Serum GDNF levels in MDD patients were significantly decreased compared to that of the control subjects (P < 0.001). Furthermore, the decrease in the serum GDNF levels positively correlated with performance in the WCST-% CONC and negatively with performance in the WCST-P in MDD patients.
DISCUSSION: The findings suggest that MDD patients have extensive impairments of executive functioning, and lower serum GDNF might be involved in the pathogenesis of MDD, which may be associated with the cognitive dysfunction in MDD patients.
Xiaobin Zhang; Bu Ru; Weiwei Sha; Wang Xin; Honghui Zhou; Yumei Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-17
Journal Detail:
Title:  Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists     Volume:  -     ISSN:  1758-5872     ISO Abbreviation:  Asia Pac Psychiatry     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101506757     Medline TA:  Asia Pac Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Publishing Asia Pty Ltd.
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