| Performance of FDG-PET/CT in the diagnosis of recurrent endometrial cancer. | |
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MedLine Citation:
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PMID: 18311534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the accuracy of integrated positron emission tomography and computed tomography (PET/CT) using 18-F-fluorodeoxyglucose (FDG), compared with PET alone, in the diagnosis of suspected endometrial cancer recurrence. METHODS: Thirty women who had undergone primary surgery for histopathologically proven endometrial cancer with suspected recurrence because of clinical, cytological, biochemical, and/or radiological findings were enrolled in this study. PET and integrated PET/CT images were evaluated by two different experienced radiologists by consensus for each modality. A final diagnosis of recurrence was confirmed by histopathology, other imaging and clinical follow-up for longer than 1 year. The statistical significance of differences between PET and PET/CT was determined by the McNemar test. RESULTS: Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET/CT were 93% (14/15), 93% (14/15), and 93% (28/30), respectively, whereas for PET, the corresponding data were 80% (12/15), 80% (12/15), and 80% (24/30), respectively (P=0.479, 0.479, and 0.134, respectively). CT from PET/CT resolved the false-positive PET results because of hyper-metabolic activity of benign inflammatory lesions and physiological variants and moreover detected lung metastasis and para-aortic lymph node metastasis that PET missed. However, tiny para-aortic lymph node metastasis could not be detected even with PET/CT. CONCLUSIONS: Integrated FDG-PET/CT is a useful complementary modality for providing good anatomic and functional localization of sites of recurrence during follow-up of patients with endometrial cancer. |
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Authors:
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Kazuhiro Kitajima; Koji Murakami; Erena Yamasaki; Shingo Hagiwara; Ichio Fukasawa; Noriyuki Inaba; Yasushi Kaji; Kazuro Sugimura |
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Publication Detail:
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Type: Journal Article Date: 2008-03-03 |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 22 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2008-05-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 103-9 Citation Subset: IM |
Affiliation:
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PET Center, Dokkyo Medical University Hospital, Mibu, Shimotuka, Tochigi, Japan. kazu10041976@yahoo.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Endometrial Neoplasms / pathology*, surgery False Negative Reactions False Positive Reactions Female Fluorodeoxyglucose F18 / diagnostic use, pharmacokinetics Humans Lung Neoplasms / radionuclide imaging, secondary Lymph Nodes / pathology Lymphatic Metastasis / radionuclide imaging Middle Aged Neoplasm Recurrence, Local / radiography, radionuclide imaging* Neoplasms, Second Primary / radiography, radionuclide imaging* Positron-Emission Tomography* / statistics & numerical data Radiopharmaceuticals / diagnostic use, pharmacokinetics Sensitivity and Specificity Tomography, X-Ray Computed* / statistics & numerical data |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
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