| Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer. | |
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MedLine Citation:
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PMID: 18425518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose is to evaluate the accuracy of integrated FDG-PET/CT, compared with PET alone, for diagnosis of suspected recurrence of uterine cervical cancer. Fifty-two women who had undergone treatment for histopathologically proven cervical cancer received PET/CT with suspected recurrence. PET-alone and integrated PET/CT images were evaluated by two different experienced radiologists by consensus for each investigation. A final diagnosis was confirmed by histopathology, radiological imaging, and clinical follow-up for over 1 year. Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET/CT were 92.0% (23/25), 92.6% (25/27), and 92.3% (48/52), respectively, while for PET, the corresponding figures were 80.0% (20/25), 77.8% (21/27), and 78.8% (41/52), respectively. PET/CT resolved the false-positive PET results due to hypermetabolic activity of benign/inflammatory lesions and physiological variants, and was able to detect lung metastasis, local recurrence, peritoneal dissemination, para-aortic lymph node metastasis, and pelvic lymph node metastasis missed by PET alone. However, tiny local recurrence and lymph node metastasis could not be detected even by PET/CT. FDG-PET/CT is a useful complementary modality for providing good anatomic and functional localization of sites of recurrence during follow-up of patients with cervical cancer. |
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Authors:
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Kazuhiro Kitajima; Koji Murakami; Erena Yamasaki; Yasushi Domeki; Yasushi Kaji; Kazuro Sugimura |
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Publication Detail:
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Type: Journal Article Date: 2008-04-19 |
Journal Detail:
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Title: European radiology Volume: 18 ISSN: 0938-7994 ISO Abbreviation: Eur Radiol Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-11 Completed Date: 2009-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 2040-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, Dokkyo University School of Medicine, 880 Kita-kobayashi, Mibu, Shimotuka-gun, Tochigi, 321-0293, Japan. kitajima@med.kobe-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Fluorodeoxyglucose F18 / diagnostic use* Humans Image Enhancement / methods* Male Middle Aged Neoplasm Recurrence, Local / diagnosis* Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* Uterine Cervical Neoplasms / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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