| Performance of Deming regression analysis in case of misspecified analytical error ratio in method comparison studies. | |
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MedLine Citation:
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PMID: 9590376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Application of Deming regression analysis to interpret method comparison data presupposes specification of the squared analytical error ratio (lambda), but in cases involving only single measurements by each method, this ratio may be unknown and is often assigned a default value of one. On the basis of simulations, this practice was evaluated in situations with real error ratios deviating from one. Comparisons of two electrolyte methods and two glucose methods were simulated. In the first case, misspecification of lambda produced a bias that amounted to two-thirds of the maximum bias of the ordinary least-squares regression method. Standard errors and the results of hypothesis-testing also became misleading. In the second situation, a misspecified error ratio resulted only in a negligible bias. Thus, given a short range of values in relation to the measurement errors, it is important that lambda is correctly estimated either from duplicate sets of measurements or, in the case of single measurement sets, specified from quality-control data. However, even with a misspecified error ratio, Deming regression analysis is likely to perform better than least-squares regression analysis. |
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Authors:
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K Linnet |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical chemistry Volume: 44 ISSN: 0009-9147 ISO Abbreviation: Clin. Chem. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-05-22 Completed Date: 1998-05-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1024-31 Citation Subset: IM |
Affiliation:
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Laboratory of Clinical Biochemistry, Psychiatric University Hospital, Risskov, Denmark. linnet@post7.tele.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bias (Epidemiology) Blood Glucose / metabolism Chemistry, Clinical / statistics & numerical data* Computer Simulation Electrolytes / blood Quality Control Regression Analysis Sodium / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Electrolytes; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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