| Performance assessment of dynamic spiral scan modes with variable pitch for quantitative perfusion computed tomography. | |
| | |
MedLine Citation:
|
PMID: 20440213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Perfusion computed tomography is increasingly being used in diagnostic radiology. Axial coverage of the traditional approach is limited to the width of the detector. Using continuous periodic table movement coverage can be increased beyond this limit. In this study, we compared tissue flow values determined from scans with a periodic spiral implementation with variable pitch with ones determined from standard dynamic scan modes. METHODS: A flow phantom (preserved porcine kidney) was scanned with 2 settings of a periodic spiral (Adaptive 4D Spiral) with a range of 100 and 148 mm and a temporal sampling of 1.5 seconds. Additionally, the whole phantom was scanned with the standard dynamic mode (detector width 38.4 mm, temporal sampling 1.0 seconds) at various overlapping positions as a reference. Scan parameters (80 kV, 140 mAs, 40s scan time) were selected similar to a typical brain perfusion study. All scans were repeated 5 times. Tissue flow was calculated with a dedicated deconvolution algorithm. In a center slice and 3 additional slices at various off center positions flow values were recorded in a total of 126 regions of interest (ROI). Reproducibility was determined from the variation of the repeat scans. Agreement between periodic spirals and standard mode was determined by Bland Altman plots and correlation analysis. RESULTS: The reproducibility of the tissue flow determination ranged from 2.7 to 4.4 mL/100 mL/min and was similar for all scan modes. The coefficient of variation ranged from 3.9% to 6.1%. Mean tissue flow in the 126 ROIs ranged from 35 to 121 mL/100 mL/min. There was excellent correlation between both periodic spiral ranges and the standard dynamic mode with a Pearson correlation coefficient of r = 0.97. The regression slope (intercept 0) for the 100 mm range was 1.01, for the 148 mm range it was 0.97. The absolute differences per ROI varied between 1.5 and 4.1 mL/100 mL/min, the relative differences between 1.9% and 6.5%. Differences did not depend on the slice location. CONCLUSIONS: Periodic spiral scan modes with variable pitch and a sampling rate of 1.5 seconds can be used for the quantitative determination of tissue flow. Their performance is equivalent to equidistant sampling with standard dynamic scan modes. The ranges of 100 and 148 mm investigated allow coverage of the whole brain or an entire organ for perfusion imaging. |
| | |
Authors:
|
Ulrike Haberland; Ernst Klotz; Nasreddin Abolmaali |
Related Documents
:
|
21227983 - An investigational study of mininum rotational pump speed to avoid retrograde flow in t... 19806433 - The influence of flow rate on the aerosol deposition profile and electrostatic charge o... 15781533 - Hyperglycemia in patients administered dexamethasone for craniotomy. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article |
Journal Detail:
|
Title: Investigative radiology Volume: 45 ISSN: 1536-0210 ISO Abbreviation: Invest Radiol Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-22 Completed Date: 2010-10-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 378-86 Citation Subset: IM |
Affiliation:
|
OncoRay-Center for Radiation Research in Oncology, TU Dresden, Germany. ulrike.haberland@siemens.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms* Humans Imaging, Three-Dimensional / methods* Perfusion Imaging / methods* Phantoms, Imaging Radiographic Image Enhancement / methods* Radiographic Image Interpretation, Computer-Assisted / methods* Reproducibility of Results Sensitivity and Specificity Tomography, Spiral Computed / instrumentation, methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dynamic Iterative Beam Hardening Correction (DIBHC) in Myocardial Perfusion Imaging Using Contrast-E...
Next Document: Differentiation of Urinary Calculi With Dual Energy CT: Effect of Spectral Shaping by High Energy Ti...