| Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis. | |
| | |
MedLine Citation:
|
PMID: 20118806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated the performance of aspartate aminotransferase to platelet ratio index (APRI) as a noninvasive marker of fibrosis and cirrhosis in children with chronic viral hepatitis. All of the patients 0 to 20 years old with chronic hepatitis B or C presenting at a tertiary medical center from 1992 to 2008 were identified. Thirty-six patients were evaluated with 48 biopsy results. The areas under the receiver operating characteristic curve were 0.71 for fibrosis and 0.52 for cirrhosis. When examining subgroups, the APRI performed better in older patients and in those with vertically transmitted hepatitis C virus. Further research into APRI and the other noninvasive markers of fibrosis in children with chronic viral hepatitis is warranted. |
| | |
Authors:
|
Katherine E McGoogan; P Brian Smith; Steve S Choi; Wallace Berman; Ravi Jhaveri |
Related Documents
:
|
7377816 - Serum ferritin, liver iron stores, and liver histology in children with thalassaemia. 8485056 - Iron status in red cell pyruvate kinase deficiency: study of italian cases. 699326 - Serum monoamine oxidase assayed with a new synthetic benzylamine derivative as substrat... 12182756 - Non-transferrin-bound iron in untreated and ribavirin-treated chronic hepatitis c patie... 16759056 - Naive hiv/hcv-coinfected patients have higher intrahepatic pro-inflammatory cytokines t... 10978186 - Identification of mk-944a: a second clinical candidate from the hydroxylaminepentanamid... |
Publication Detail:
|
Type: Journal Article; Validation Studies |
Journal Detail:
|
Title: Journal of pediatric gastroenterology and nutrition Volume: 50 ISSN: 1536-4801 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-03-01 Completed Date: 2010-08-17 Revised Date: 2012-04-02 |
Medline Journal Info:
|
Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 344-6 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Age Factors Aspartate Aminotransferases / analysis* Biological Markers / blood Child Child, Preschool Female Fibrosis Hepatitis B, Chronic / blood*, pathology Hepatitis C, Chronic / blood*, pathology, transmission Humans Infant Liver / enzymology, pathology*, virology Liver Cirrhosis / diagnosis*, etiology Male Platelet Count ROC Curve Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
K23 HD060040-01/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; EC 2.6.1.1/Aspartate Aminotransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Functional Constipation in Children: A Systematic Review on Prognosis and Predictive Factors.
Next Document: Protection of Intestinal Occludin Tight Junction Protein by Dietary Gangliosides in Lipopolysacchari...