Document Detail


Performance of (18)F-FDG PET/contrast-enhanced CT in the staging of squamous cell carcinoma of the oral cavity and oropharynx.
MedLine Citation:
PMID:  21824748     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this study was to assess the diagnostic value of integrated whole body positron emission tomography/contrast-enhanced CT (PET/CECT) as a one step examination in the initial staging of oral and oropharyngeal squamous cell carcinoma (OOSCC). Seventy three consecutive OOSCC patients who underwent PET/CECT for initial staging and tumour resection and neck dissection as primary treatment, were included. For each PET/CECT result, the contribution of fluorine-18 fluorodeoxyglucose ((18)F-FDG)-uptake and radiologic criteria was assessed. PET/CECT results were correlated to histological specimens obtained with tumour resection and neck dissection. For detecting the primary tumour PET/CECT showed a sensitivity of 96% and for detecting cervical metastases a sensitivity and specificity of 89% and 81%, respectively. In the clinically N0 subgroup (n=37), PET/CECT showed a sensitivity and specificity of 64% and 81%, respectively. In five of six patients PET/CECT detected a second primary tumour. The results show that the use of diagnostic PET/CECT as a one step examination is a reliable alternative for PET/CT in combination with a separate diagnostic CT in patients with OOSC for initial staging. The need for treatment of the neck in the clinically negative neck should not be based on PET/CECT results only, due to the risk of missing a small metastasis.
Authors:
C A Krabbe; H Balink; J L N Roodenburg; J Dol; J G A M de Visscher
Related Documents :
19822868 - Relationships between biomarkers in aging and dementia.
22521178 - Imaging in lower urinary tract infections.
12902408 - Clinical performance of pet/ct in evaluation of cancer: additional value for diagnostic...
21590248 - 18f-2-fluoro-2-deoxy-d-glucose positron emission tomography of head and neck in patient...
6694778 - Thallium-201 myocardial imaging in patients on chronic hemodialysis.
12087438 - 3d volume rendering using multislice ct for dental implants.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-6
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  -     ISSN:  1399-0020     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, The Netherlands; Department of Oral and Maxillofacial Surgery, Medical Center Leeuwarden, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Psychometric properties and norms of the German ABC-Community and PAS-ADD Checklist.
Next Document:  Left atrial thrombus and prognosis after anticoagulation therapy in patients with atrial fibrillatio...