Document Detail

Perforated peptic ulcer disease: mid-term outcome among Iranian population.
MedLine Citation:
PMID:  20872324     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The aim of this study was to evaluate midterm outcome of patients with perforated peptic ulcer disease and to determine the main predictors of mid-term mortality.
METHODS: Demographic and clinical characteristics of 56 patients with the diagnosis of perforated peptic ulcer who were hospitalized in Taleghani Hospital over a 10-year period (19962005) were retrospectively collected, and in-hospital mortality and morbidity were determined. Patients were also followed for one month, one year and five years after the operation.
RESULTS: Among these patients, 85.5% were treated with omental patch closure, 7.1% underwent vagotomy pyloroplasty, 5.3% underwent concurrent vagotomy and gastrojejunostomy, and 1.8% underwent antrectomy. In-hospital mortality and morbidity were 5.3% and 48.2%, respectively. Survival rates at one month, one year and five years after the operation were 92.9%, 89.3% and 78.6%, respectively. Advanced age (p=0.001), preoperative shock (p=0.003), history of malignancy before surgery (p=0.001), treatment delay (p=0.028), intensive care unit admission (p=0.032), and size of ulcer >5 cm (p=0.043) were the main predictors of five-year mortality in the followed patients.
CONCLUSIONS: Mid-term mortality of treated perforated peptic ulcer disease among our population was notable, and the main predictors of mortality included advanced age, history of malignancy, treatment delay, intensive care unit admission, and ulcer size.
Freshteh Kamani; Mehrdad Moghimi; Seyed Ali Marashi; Habibollah Peyrovi; Mehrdad Sheikhvatan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology     Volume:  21     ISSN:  1300-4948     ISO Abbreviation:  Turk J Gastroenterol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9515841     Medline TA:  Turk J Gastroenterol     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
Department of Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Middle Aged
Peptic Ulcer Perforation / mortality*,  surgery*
Retrospective Studies
Time Factors
Treatment Outcome
Young Adult

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