| Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project. | |
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MedLine Citation:
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PMID: 20819969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are man-made compounds with widespread presence in human sera. In previous occupational and adult studies, PFOA and PFOS were positively associated with serum lipid levels. OBJECTIVE: To interrogate associations between PFOA and PFOS and serum lipids in children and adolescents. DESIGN: Cross-sectional community-based study. SETTING: Mid-Ohio River Valley. PARTICIPANTS: A total of 12 476 children and adolescents included in the C8 Health Project, which resulted from the pretrial settlement of a class action lawsuit pursuant to PFOA contamination of the drinking water supply. MAIN OUTCOME MEASURES: Serum lipids (total, high-density lipoprotein [HDL-C], and low-density lipoprotein [LDL-C] cholesterol and fasting triglycerides). RESULTS: Mean (SD) serum PFOA and PFOS concentrations were 69.2 (111.9) ng/mL and 22.7 (12.6) ng/mL, respectively. In linear regression after adjustment for covariables, PFOA was significantly associated with increased total cholesterol and LDL-C, and PFOS was significantly associated with increased total cholesterol, HDL-C, and LDL-C. Using general linear model analysis of covariance, between the first and fifth quintiles of PFOA there was a 4.6-mg/dL and a 3.8-mg/dL increase in the adjusted mean levels of total cholesterol and LDL-C levels, respectively, and an 8.5-mg/dL and a 5.8-mg/dL increase in the adjusted mean levels of total cholesterol and LDL-C, respectively, between the first and fifth quintiles of PFOS. Increases were 10 mg/dL for some age- and sex-group strata. Observed effects were nonlinear, with larger increases in total cholesterol and LDL-C levels occurring at the lowest range, particularly of PFOA. CONCLUSION: Although the epidemiologic and cross-sectional natures of this study limit causal inferences, the consistently observed associations between increasing PFOA and PFOS and elevated total cholesterol and LDL-C levels warrant further study. |
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Authors:
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Stephanie J Frisbee; Anoop Shankar; Sarah S Knox; Kyle Steenland; David A Savitz; Tony Fletcher; Alan M Ducatman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of pediatrics & adolescent medicine Volume: 164 ISSN: 1538-3628 ISO Abbreviation: Arch Pediatr Adolesc Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-07 Completed Date: 2010-09-24 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 9422751 Medline TA: Arch Pediatr Adolesc Med Country: United States |
Other Details:
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Languages: eng Pagination: 860-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Community Medicine, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, 1 Medical Center Drive, Morgantown, WV 26506-9105, USA. sfrisbee@hsc.wvu.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alkanesulfonic Acids / blood* Chemical Industry Child Child, Preschool Cholesterol / blood Cholesterol, LDL / blood Cross-Sectional Studies Environmental Exposure Female Fluorocarbons / blood* Humans Infant Infant, Newborn Lipids / blood* Logistic Models Male Octanoic Acids / blood* Water Supply |
| Grant Support | |
ID/Acronym/Agency:
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R03 ES018888-01/ES/NIEHS NIH HHS; R03 ES018888-02/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Alkanesulfonic Acids; 0/Cholesterol, LDL; 0/Fluorocarbons; 0/Lipids; 0/Octanoic Acids; 1763-23-1/perfluorooctane sulfonic acid; 335-67-1/perfluorooctanoic acid; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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