Document Detail


Perfluorooctanesulfonate and related fluorochemicals in human blood samples from China.
MedLine Citation:
PMID:  16509308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perfluorooctanesulfonylfluoride (POSF)-based compounds have been manufactured and used in a variety of industrial applications. These compounds degrade to perfluorooctanesulfonate (PFOS) which is regarded as a persistent end-stage metabolite and is found to accumulate in tissues of humans and wildlife. PFOS, perfluorohexanesulfonate (PFHxS), perfluorooctanoate (PFOA), and perfluorooctanesulfonamide (PFOSA) have been found in human sera from the United States. In this study, concentrations of PFHxS, perfluorobutanesulfonate (PFBS), PFOS, perfluorohexanoic acid (PFHxA), PFOA, perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and PFOSA were measured in 85 samples of whole human blood collected from nine cities (eight provinces) in China, including Shenyang (Liaoning), Beijing (Hebei), Zhengzhou (Henan), Jintan (Jiangsu), Wuhan (Hubei), Zhoushan (Zhejiang), Guiyang (Guizhou), Xiamen (Fujian), and Fuzhou (Fujian). Among the 10 perfluorinated compounds (PFCs) measured, PFOS was the predominant compound. The mean concentration of PFOS was greatest in samples collected from Shenyang (79.2 ng/mL) and least in samples from Jintan (3.72 ng/mL). PFHxS was the next most abundant perfluorochemical in the samples. No age-related differences in the concentrations of PFOA, PFOS, PFOSA, and PFHxS were observed. Gender-related differences were found,with males higher for PFOS and PFHxS, and females higher in PFUnDA. Concentrations of PFHxS were positively correlated with those of PFOS, while concentrations of PFNA, PFDA, and PFUnDA were positively correlated with those of PFOA. There were differences in the concentration profiles (percentage composition) of various PFCs in the samples among the nine cities.
Authors:
Leo W Y Yeung; M K So; Guibin Jiang; S Taniyasu; N Yamashita; Maoyong Song; Yongning Wu; Jingguang Li; J P Giesy; K S Guruge; Paul K S Lam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental science & technology     Volume:  40     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-02     Completed Date:  2006-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  715-20     Citation Subset:  IM    
Affiliation:
Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Alkanesulfonic Acids / blood*
Child
China
Environmental Pollutants / blood*
Female
Fluorocarbons / blood*
Humans
Industry
Male
Manufactured Materials
Middle Aged
Urban Population
Chemical
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Environmental Pollutants; 0/Fluorocarbons; 1763-23-1/perfluorooctane sulfonic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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