Document Detail

Perfluorooctane sulphonate (PFOS) and perfluorooctanoic acid (PFOA) in human breast milk: results of a pilot study.
MedLine Citation:
PMID:  17870667     Owner:  NLM     Status:  MEDLINE    
Perfluorinated compounds (PFC) are a large group of chemicals produced for several decades and widely used for many industrial and consumer applications. Because of their global occurrence in different environmental media, their persistence and their potential to bioaccumulate in organisms they are of toxicological and public concern. In the present study, perfluorooctane sulphonate (PFOS) and perfluorooctanoic acid (PFOA) were quantified in 70 breast milk samples. Samples were obtained from Leipzig, Germany (38 archived samples), Munich, Germany (19 fresh samples) and Gyor, Hungary (13 frozen samples). PFOS could be quantified in all 70 samples. The concentration in samples from Germany ranged between 28 and 309 ng/l (median: 119 ng/l). Samples from Hungary showed significantly higher PFOS concentrations (median 330 ng/l, range 96-639 ng/l). In only 11 of 70 samples (16%) PFOA reached the LOQ (200 ng/l); values ranged from 201 to 460 ng/l. If only those samples with PFOA values above the LOQ were considered, we found a significant correlation between the PFOS and PFOA concentrations (r=0.75, p=0.008). Based on the results of the German sample, we estimated an intake of 0.10 microg PFOS/day (using median) or 0.27 PFOS microg/day (using maximum value) via breast milk for an infant of 5 kg bodyweight. Our data suggest that fully breastfed infants are unlikely to exceed the recommended tolerable daily intake of PFC. However, more target-oriented studies are needed to identify the amount and time-trend of PFOS and PFOA in maternal blood during pregnancy, after delivery, as well as in the growing infant and in its diet (e.g., breast milk and formula).
W Völkel; O Genzel-Boroviczény; H Demmelmair; C Gebauer; B Koletzko; D Twardella; U Raab; H Fromme
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-09-17
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  211     ISSN:  1438-4639     ISO Abbreviation:  Int J Hyg Environ Health     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2009-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  440-6     Citation Subset:  IM    
Bavarian Health and Food Safety Authority, Department of Environmental Health, Veterinaerstrasse 2, 85764 Oberschleissheim, Germany.
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MeSH Terms
Alkanesulfonic Acids / analysis*
Chromatography, Liquid
Fluorocarbons / analysis*
Mass Spectrometry
Milk, Human / chemistry*
Octanoic Acids / analysis*
Pilot Projects
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Fluorocarbons; 0/Octanoic Acids; 1763-23-1/perfluorooctane sulfonic acid; 335-67-1/perfluorooctanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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