Document Detail


Perfluorodecanoic acid as a useful pharmacologic tool for the study of peroxisome proliferation.
MedLine Citation:
PMID:  8981056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The phenomena of peroxisome proliferation in rodent liver has received considerable attention due to its association with hepatocellular carcinoma. Chemicals that cause peroxisome proliferation include several structurally unrelated hypolipidemic drugs, phthalate esters and halogenated solvents. The mechanism by which peroxisome proliferators exert their beneficial (hypolipidemia) as well as their toxic (cancer) effects is still largely unknown. Perfluorodecanoic acid (PFDA) is a potent peroxisome proliferator in rodent liver that resembles other members of this chemical class in many aspects, including its effects on gene expression and fatty acid metabolism. However, there are many dissimilarities between PFDA and hypolipidemic peroxisome proliferators that have not been extensively explored. PFDA is unlike other peroxisome proliferators in parent compound metabolism, hypolipidemia, and tumor promotion. The present review article will discuss what is currently known about PFDA and how it may be utilized to dissect the mechanism of action of an important group of hypolipidemic drug and environmental pollutant, the peroxisome proliferators.
Authors:
J P Vanden Heuvel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  General pharmacology     Volume:  27     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-04-01     Completed Date:  1997-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1123-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, School of Pharmacy, Purdue University, West Lafayette, IN 47907 USA. VANDENHEUVEL@ACLCB.PURDUE.EDU
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / pharmacology
Decanoic Acids / pharmacology*
Fluorocarbons / pharmacology*
Humans
Lipid Metabolism
Liver / drug effects,  metabolism,  ultrastructure
Microbodies / drug effects*
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Decanoic Acids; 0/Fluorocarbons; 335-76-2/perfluorodecanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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