| Perfluorocarbon-based oxygen delivery. | |
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MedLine Citation:
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PMID: 17090429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The basic properties of perfluorocarbons (PFCs) and PFC emulsions relevant to their use as oxygen delivery systems are briefly reviewed. The key issues related to the selection of an appropriate, readily excretable PFC and the engineering of a stable injectable PFC emulsion are discussed. Oxygent, a terminally heat-sterilized, injectable 60% w/v PFC emulsion made primarily of F-octyl bromide and a few percent of F-decyl bromide, with egg phospholipids as an emulsifier, has been developed. Its efficacy in avoiding and reducing red cell transfusion during surgery has been established during a Phase III clinical evaluation. Another Phase III clinical trial in cardiopulmonary bypass surgery, with a protocol that included both augmented-acute normovolemic hemodilution and intraoperative autologous donation, has, however, been interrupted following the observation of adverse events. Data analysis assigned these events to an inappropriate study protocol. A search for possible interactions between Oxygent and fluids present during cardiopulmonary bypass surgery detected no effect of the emulsion on hemostasis, hemolysis and blood rheology. |
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Authors:
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Jean G Riess |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 34 ISSN: 1073-1199 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 2006 |
Date Detail:
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Created Date: 2006-11-08 Completed Date: 2006-12-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 567-80 Citation Subset: IM |
Affiliation:
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MRI Institute, University of California at San Diego and Alliance Pharmaceutical Corp., San Diego, CA 92103, USA. jriess@allp.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Substitutes
/
chemistry,
pharmacology,
therapeutic use* Clinical Trials as Topic Emulsions Fluorocarbons / chemistry, therapeutic use* Hemolysis / drug effects* Hemorheology / drug effects* Hemostasis / drug effects* Humans |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Emulsions; 0/Fluorocarbons; 423-55-2/perflubron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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