| Perfluorocarbon-based oxygen carriers: review of products and trials. | |
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MedLine Citation:
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PMID: 20698841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A viable blood substitute is still of great necessity throughout the world. Perfluorocarbon-based oxygen carriers (PFCOCs) are emulsions that take advantage of the high solubility of respiratory gases in perfluorocarbons (PFCs). Despite attractive characteristics, no PFCOC is currently approved for clinical uses. Some PFCOCs have failed due to secondary effects of the surfactants employed, like Fluosol DA, whereas others to adverse cerebrovascular effects on cardiopulmonary bypass, such as Oxygent. Further in-depth, rigorous work is needed to overcome the annotated failures and to obtain a safe PFCOC approved for human use. The aim of this study is to review in detail the most-used PFCOCs, their formulation, and preclinical and clinical trials, and to reflect upon causes of failure and strategies to overcome such failures. |
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Authors:
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Camila Irene Castro; Juan Carlos Briceno |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Artificial organs Volume: 34 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 622-34 Citation Subset: IM |
Affiliation:
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Blood Substitutes Laboratory, Fundación Cardio Infantil-Universidad de los Andes, Bogota, Colombia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Substitutes / chemistry, therapeutic use* Clinical Trials as Topic Emulsions / chemistry, therapeutic use Fluorocarbons / chemistry, therapeutic use* Humans Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Emulsions; 0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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