Document Detail


Perfluorinated compounds in human milk from Massachusetts, U.S.A.
MedLine Citation:
PMID:  18497172     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perfluorinated compounds (PFCs), notably perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA), have been reported in human blood. Furthermore, the occurrence of PFCs in the blood of newborn babies, coupled with the need to study the potential association of PFC exposure with birth outcomes in neonates, suggests the need for determining the sources and magnitude of exposure in infants. In this study, nine PFCs were measured in 45 human breast milk samples collected in 2004 from Massachusetts, U.S.A. PFOS and PFOA were the predominant PFCs found at mean concentrations of 131 and 43.8 pg/mL, respectively. Comparison of the ratio of PFOS to PFOA in human milk with the ratios published for human serum from the U.S. female population suggested preferential partitioning of PFOA to milk. Concentrations of PFOA were significantly higher in the milk of mothers nursing for the first time (n = 34) than in the milk of mothers who have previously nursed (n = 8). Based on the estimated body weight and milk intake, the average and highest daily intakes of total PFCs by infants were 23.5 and 87.1 ng/kg bw, respectively. We found that the daily ingestion rates of PFOS and PFOA did not exceed the tolerable daily intake recommended by the U.K. Food Standards Agency. This is the first study to measure the occurrence of PFCs in human milk from the U.S.A.
Authors:
Lin Tao; Kurunthachalam Kannan; Chung M Wong; Kathleen F Arcaro; John L Butenhoff
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Environmental science & technology     Volume:  42     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3096-101     Citation Subset:  IM    
Affiliation:
Wadsworth Center, New York State Department of Health, Albany, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Environmental Monitoring
Environmental Pollutants / analysis*
Female
Fluorocarbons / analysis*
Humans
Massachusetts
Maternal Exposure
Milk, Human / chemistry*
Grant Support
ID/Acronym/Agency:
U59/EH223392-05/EH/NCEH CDC HHS
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Fluorocarbons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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