| Perfluorinated compounds in relation to birth weight in the Norwegian Mother and Child Cohort Study. | |
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MedLine Citation:
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PMID: 22517810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perfluorooctane sulfonate and perfluorooctanoic acid are perfluorinated compounds (PFCs) widely distributed in the environment. Previous studies of PFCs and birth weight are equivocal. The authors examined this association in the Norwegian Mother and Child Cohort Study (MoBa), using data from 901 women enrolled from 2003 to 2004 and selected for a prior case-based study of PFCs and subfecundity. Maternal plasma samples were obtained around 17 weeks of gestation. Outcomes included birth weight z scores, preterm birth, small for gestational age, and large for gestational age. The adjusted birth weight z scores were slightly lower among infants born to mothers in the highest quartiles of PFCs compared with infants born to mothers in the lowest quartiles: for perfluorooctane sulfonate, β = -0.18 (95% confidence interval: -0.41, 0.05) and, for perfluorooctanoic acid, β = -0.21 (95% confidence interval: -0.45, 0.04). No clear evidence of an association with small for gestational age or large for gestational age was observed. Perfluorooctane sulfonate and perfluorooctanoic acid were each associated with decreased adjusted odds of preterm birth, although the cell counts were small. Whether some of the associations suggested by these findings may be due to a noncausal pharmacokinetic mechanism remains unclear. |
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Authors:
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Kristina W Whitworth; Line S Haug; Donna D Baird; Georg Becher; Jane A Hoppin; Rolv Skjaerven; Cathrine Thomsen; Merete Eggesbo; Gregory Travlos; Ralph Wilson; Lea A Cupul-Uicab; Anne Lise Brantsaeter; Matthew P Longnecker |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2012-04-19 |
Journal Detail:
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Title: American journal of epidemiology Volume: 175 ISSN: 1476-6256 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-12 Completed Date: 2012-08-16 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 1209-16 Citation Subset: IM |
Affiliation:
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National Institute for Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA. whitworthkw@niehs.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alkanesulfonic Acids / blood, toxicity* Birth Weight / drug effects* Caprylates / blood, toxicity* Diet Surveys Environmental Pollutants / blood, toxicity* Female Fetal Macrosomia / chemically induced* Fluorocarbons / blood, toxicity* Food Contamination Humans Infant, Newborn Infant, Small for Gestational Age Maternal Exposure / adverse effects* Norway Odds Ratio Pregnancy Premature Birth / chemically induced* Prospective Studies Seafood Single-Blind Method |
| Grant Support | |
ID/Acronym/Agency:
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1 UO1 NS 047537-01/NS/NINDS NIH HHS; N01-ES-85433/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Alkanesulfonic Acids; 0/Caprylates; 0/Environmental Pollutants; 0/Fluorocarbons; 1763-23-1/perfluorooctane sulfonic acid; 335-67-1/perfluorooctanoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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