Document Detail

Perfluorinated compounds in relation to birth weight in the Norwegian Mother and Child Cohort Study.
MedLine Citation:
PMID:  22517810     Owner:  NLM     Status:  MEDLINE    
Perfluorooctane sulfonate and perfluorooctanoic acid are perfluorinated compounds (PFCs) widely distributed in the environment. Previous studies of PFCs and birth weight are equivocal. The authors examined this association in the Norwegian Mother and Child Cohort Study (MoBa), using data from 901 women enrolled from 2003 to 2004 and selected for a prior case-based study of PFCs and subfecundity. Maternal plasma samples were obtained around 17 weeks of gestation. Outcomes included birth weight z scores, preterm birth, small for gestational age, and large for gestational age. The adjusted birth weight z scores were slightly lower among infants born to mothers in the highest quartiles of PFCs compared with infants born to mothers in the lowest quartiles: for perfluorooctane sulfonate, β = -0.18 (95% confidence interval: -0.41, 0.05) and, for perfluorooctanoic acid, β = -0.21 (95% confidence interval: -0.45, 0.04). No clear evidence of an association with small for gestational age or large for gestational age was observed. Perfluorooctane sulfonate and perfluorooctanoic acid were each associated with decreased adjusted odds of preterm birth, although the cell counts were small. Whether some of the associations suggested by these findings may be due to a noncausal pharmacokinetic mechanism remains unclear.
Kristina W Whitworth; Line S Haug; Donna D Baird; Georg Becher; Jane A Hoppin; Rolv Skjaerven; Cathrine Thomsen; Merete Eggesbo; Gregory Travlos; Ralph Wilson; Lea A Cupul-Uicab; Anne Lise Brantsaeter; Matthew P Longnecker
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2012-04-19
Journal Detail:
Title:  American journal of epidemiology     Volume:  175     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2012-08-16     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1209-16     Citation Subset:  IM    
National Institute for Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA.
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MeSH Terms
Alkanesulfonic Acids / blood,  toxicity*
Birth Weight / drug effects*
Caprylates / blood,  toxicity*
Diet Surveys
Environmental Pollutants / blood,  toxicity*
Fetal Macrosomia / chemically induced*
Fluorocarbons / blood,  toxicity*
Food Contamination
Infant, Newborn
Infant, Small for Gestational Age
Maternal Exposure / adverse effects*
Odds Ratio
Premature Birth / chemically induced*
Prospective Studies
Single-Blind Method
Grant Support
1 UO1 NS 047537-01/NS/NINDS NIH HHS; N01-ES-85433/ES/NIEHS NIH HHS
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Caprylates; 0/Environmental Pollutants; 0/Fluorocarbons; 1763-23-1/perfluorooctane sulfonic acid; 335-67-1/perfluorooctanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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