| Perflubron emulsion increases subcutaneous tissue oxygen tension in rats. | |
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MedLine Citation:
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PMID: 16476072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxygen plays a central role in wound healing. The hypothesis of this study was that the administration of a perfluorocarbon emulsion, which dissolves oxygen will increase subcutaneous tissue oxygen tension (PsqO2) in normovolemic and hemorrhaged animals. In the first set of experiments, PsqO2 was measured with a polarographic oxygen electrode along the dorsum of normovolemic-anesthetized rats (n=20) breathing supplemental oxygen. After baseline equilibration of tissue oxygen tension, perflubron emulsion (n=12) or saline control (n=8) was administered. Perflubron administration increased PsqO2 by 32.0 +/- 7.2 mmHg, whereas saline administration had no effect (-1.0 +/- 6.6 mmHg). In a second set of experiments, PsqO2 (n=12) was measured in rats breathing 100 percent oxygen after being bled 20 percent of their blood volume. Creating hypovolemic rats allowed for the study of the effect of perflubron emulsion administration on subcutaneous oxygen tension in tissues with compromised blood flow. Perflubron emulsion was only effective at increasing oxygen tension in tissues with oxygen extractions less then 2.0 vol%. These findings agree with those results analytically predicted based on the oxygen solubility of the perflubron emulsion. |
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Authors:
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Noah A Rosen; Harriet W Hopf; Thomas K Hunt |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society Volume: 14 ISSN: 1067-1927 ISO Abbreviation: Wound Repair Regen Publication Date: 2006 Jan-Feb |
Date Detail:
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Created Date: 2006-02-14 Completed Date: 2006-08-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9310939 Medline TA: Wound Repair Regen Country: United States |
Other Details:
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Languages: eng Pagination: 55-60 Citation Subset: IM |
Affiliation:
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Department of Surgery, Boston University Medical Center, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Emulsions Fluorocarbons / pharmacology* Hemodynamics / drug effects Hypovolemia / metabolism Injections Oxygen / metabolism* Oxygen Consumption Rats Rats, Sprague-Dawley Subcutaneous Tissue / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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P50 GM27345/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Emulsions; 0/Fluorocarbons; 423-55-2/perflubron; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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