| Perfect timing: Epigenetic regulation of the circadian clock. | |
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MedLine Citation:
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PMID: 21536041 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post-genetic molecular mechanism is one of the routes by which phenotype is shaped. Phenotypes that arise without a concomitant mutation of the underlying genome are termed epigenetic phenomena. Here we discuss epigenetic phenomena from histone and DNA modification as it pertains to the dynamic regulatory processes of the circadian clock. Epigenetic phenomena certainly explain some regulatory aspects of the mammalian circadian oscillator. |
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Authors:
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Jürgen A Ripperger; Martha Merrow |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-29 |
Journal Detail:
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Title: FEBS letters Volume: - ISSN: 1873-3468 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biology, Unit of Biochemistry, Faculty of Sciences, University of Fribourg, Fribourg, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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