Document Detail

Percutaneous valve replacement in a young adult for radiation-induced aortic stenosis.
MedLine Citation:
PMID:  22450861     Owner:  NLM     Status:  Publisher    
A 46-year-old woman known with relapsing Hodgkin's lymphoma diagnosed at age 5, treated with repeated cycles of radiotherapy and chemotherapy, presented with severe symptomatic radiation-induced aortic stenosis. She also had other late sequelae of radiotherapy including thyroid cancer, mediastinal fribrosis and left pulmonary fibrosis with severe restrictive lung disease and a newly diagnosed renal carcinoma. Due to the prohibitively high surgical risk and need for urgent treatment, she underwent successful transcatheter aortic valve replacement with transfemoral implantation of a 23 mm Edwards SAPIEN-XT prosthesis, which was performed without valvuloplasty of the noncalcified fibrotic valve. The final result was excellent with reduction of the transaortic gradient and no residual aortic regurgitation.
Azeem Latib; Matteo Montorfano; Filippo Figini; Francesco Maisano; Alaide Chieffo; Stefano Benussi; Raimondo Bellanca; Chiara Gerli; Pietro Spagnolo; Ottavio Alfieri; Antonio Colombo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  -     ISSN:  1558-2035     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aInterventional Cardiology Unit, San Raffaele Scientific Institute bInterventional Cardiology Unit, EMO-GVM Centro Cuore Columbus cDepartment of Cardiac Surgery, San Raffaele Scientific Institute dDepartment of Cardiac Anesthesia, San Raffaele Scientific Institute eCentre for Cardiovascular Prevention, San Raffaele Scientific Institute, Milan, Italy.
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