| Percutaneous removal of pulmonary artery emboli with Hydrolyser catheter in pigs. | |
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MedLine Citation:
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PMID: 11339145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy and safety of the Hydrolyser catheter for percutaneous treatment of massive pulmonary embolism in pigs. MATERIALS AND METHODS: Twelve pigs, each weighing between 55 kg and 89 kg, were used. Radioopaque 9 cm x 0.8 cm and 4.5 cm x 0.8 cm clots, produced by mixing pig blood with iodinated contrast agent in vacutainers, were injected via the jugular vein until central pulmonary embolism (main and proximal lobar arteries) was obtained with significant systemic and pulmonary hemodynamic modifications. From a femoral approach, the 7-French Hydrolyser thrombectomy catheter was run over a 0.025-inch (0.64-mm) guide wire to remove the pulmonary emboli. Hemodynamic, gasometric and angiographic monitoring was performed before and after treatment. The procedure's safety and completeness of emboli removal was assessed by cardiopulmonary autopsy. RESULTS: Three of the 12 pigs died during embolization. Thrombectomy was therefore performed in 9, and central emboli could be obtained in 7 of the 9. The Hydrolyser could be manipulated only in central pulmonary arteries and could aspirate only central emboli in 5 of the 7 pigs that had them. Despite minimal angiographic improvement seen in these 5, there was no significant hemodynamic and gasometric improvement after treatment. The procedure induced an increase in free hemoglobin blood levels. Autopsies revealed an average of 2 endothelial injuries per pig (mainly adherent endocardial thrombi) in both nontreated (n = 3) and Hydrolyser-treated (n = 9) groups. CONCLUSION: The Hydrolyser thrombectomy catheter can be promptly positioned and easily steered in central pulmonary arteries. It can be used to partially remove central emboli, but not peripheral pulmonary emboli. Most of the injuries observed may not have been strictly related to Hydrolyser use. The pig might not be a suitable animal model for treatment of massive pulmonary embolism. |
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Authors:
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L Lacoursière; S Millward; J P Veinot; M Labinaz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes Volume: 52 ISSN: 0846-5371 ISO Abbreviation: Can Assoc Radiol J Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-05-07 Completed Date: 2001-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8812910 Medline TA: Can Assoc Radiol J Country: Canada |
Other Details:
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Languages: eng Pagination: 118-25 Citation Subset: IM |
Affiliation:
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Hôpital Laval, Département d'Imagerie Médicale, 2725 Chemin Ste-Foy, Ste-Foy, QC G1V 4G5. luc.lacoursiere@rad.ulaval.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catheterization* Female Fluoroscopy Male Pulmonary Embolism / radiography, therapy* Radiography, Interventional* Swine Thrombectomy / instrumentation* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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