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Percutaneous radiofrequency ablation for hepatocellular carcinoma: clinical outcome and safety in elderly patients.
MedLine Citation:
PMID:  23256123     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND AND AIMS. We aimed to compare clinical outcomes and safety of radiofrequency ablation (RFA) in single hepatocellular carcinoma (HCC) patients aged > 75 years (elderly group) versus patients aged < 75 years (control group). PATIENTS AND METHODS. There were 130 patients in the elderly group and 238 in the control group. Clinical outcomes including overall survival (OS), recurrence free survival (RFS) and local tumor progression (LTP), and safety were analysed for these two groups after initial RFA. RESULTS. The mean (+/- standard deviation [SD]) tumor diameter in the elderly and the control groups was 2.13 +/- 0.86 cm and 1.92 +/- 0.63 cm, respectively; the mean (+/- SD) observation period was 2.5 +/- 1.8 years and 3.2 +/- 2.0 years, respectively. The 1 and 3 year OS rates were 90.0 and 64.1%, respectively, in the elderly group and 97.6 and 83.7%, respectively, in the control group (P=0.001); the corresponding RFS rates were 66.9 and 21.3%, respectively, in the elderly group and 80.5 and 40.0%, respectively, in the control group (P=0.001). The 1 and 3 year LTP rates were 15.0 and 43.0%, respectively, in the elderly group and 8.3 and 26.3%, respectively, in the control group (P=0.002). In terms of duration of hospitalization (P=0.807) and serious adverse events related RFA (P=0.670), there was no significant difference between these two groups. CONCLUSION. The clinical outcomes in the elderly group were poorer than those in the control group, although RFA in the elderly patients was a safe procedure.
Hiroki Nishikawa; Yukio Osaki; Eriko Iguchi; Haruhiko Takeda; Yoshiaki Ohara; Azusa Sakamoto; Keiichi Hatamaru; Shinichiro Henmi; Sumio Saito; Akihiro Nasu; Ryuichi Kita; Toru Kimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastrointestinal and liver diseases : JGLD     Volume:  21     ISSN:  1842-1121     ISO Abbreviation:  J Gastrointestin Liver Dis     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101272825     Medline TA:  J Gastrointestin Liver Dis     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  397-405     Citation Subset:  IM    
Department of Gastroeneterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan; Email:
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