Document Detail

Percutaneous and off-pump treatments for functional mitral regurgitation.
MedLine Citation:
PMID:  18414987     Owner:  NLM     Status:  MEDLINE    
A new era in the treatment of functional mitral regurgitation is emerging with new devices that can be placed percutaneously or minimally invasively without cardiopulmonary bypass. These devices are categorized into three groups: annuloplasty, edge-to-edge repair, and ventricular reshaping. Percutaneous annuloplasty devices, implanted via the coronary sinus, mimic surgical annuloplasty by reducing the mitral annular anterior-posterior (or septal-lateral) dimension. Several devices, such as the PTMA, CARILLON, Monarch, and PS3 systems, are in clinical trials. Percutaneous edge-to-edge repair devices mimic the surgical Alfieri edge-to-edge repair technique, creating a double-orifice mitral valve; of these, MitraClip is in clinical trials. Ventricular reshaping devices treat both mitral annular dilatation and papillary muscle displacement (and thus leaflet tethering). The surgical Coapsys device is currently in clinical trials, and its percutaneous "interventional" version, iCoapsys, is being prepared for a clinical trial. Numerous issues need to be addressed before these devices can become standard therapies for functional mitral regurgitation. Device safety and efficacy must be demonstrated in carefully designed clinical trials with the goal of achieving outcomes equal to or better than those of surgical repair.
Kiyotaka Fukamachi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-04-15
Journal Detail:
Title:  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs     Volume:  11     ISSN:  1434-7229     ISO Abbreviation:  J Artif Organs     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-16     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815648     Medline TA:  J Artif Organs     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  12-8     Citation Subset:  IM    
Department of Biomedical Engineering / ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
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MeSH Terms
Cardiac Surgical Procedures / instrumentation*,  methods
Cardiopulmonary Bypass
Coronary Artery Bypass, Off-Pump
Mitral Valve / surgery*
Mitral Valve Insufficiency / surgery*
Surgical Procedures, Minimally Invasive / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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