| Percutaneous mitral valve repair for chronic ischemic mitral regurgitation: a real-time three-dimensional echocardiographic study in an ovine model. | |
| | |
MedLine Citation:
|
PMID: 15851597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Although surgical annuloplasty is the standard repair for ischemic mitral regurgitation (IMR), its application is limited by high morbidity and mortality. Using 2D and real-time 3D echocardiography in an ovine model of chronic IMR, we evaluated the geometric impact and short-term efficacy of a percutaneous transvenous catheter-based approach for mitral valve (MV) repair using a novel annuloplasty device placed in the coronary sinus. METHODS AND RESULTS: Six sheep developed IMR 8 weeks after induced posterior myocardial infarction. An annuloplasty device optimized to reduce anterior-posterior (A-P) mitral annular dimension and MR was placed percutaneously in the coronary sinus. Mitral annular A-P and commissure-commissure dimensions and MV tenting area (MVTa) in 3 parallel A-P planes (medial, central, and lateral) were assessed by real-time 3D echocardiography with 3D software. The annuloplasty device reduced MR jet area from 5.4+/-2.6 to 1.3+/-0.9 cm2 (P<0.01), mitral annular A-P dimension in both systole and diastole (24.3+/-2.5 to 19.7+/-2.4 mm; P<0.03; 31.0+/-3.9 to 24.7+/-2.1 mm; P<0.001), and MVTa at mid systole in all 3 planes (153+/-46 to 93+/-24 mm2, P<0.01; 140+/-47 to 88+/-23 mm2, P<0.03; and 103+/-23 to 87+/-26 mm2, P<0.03). CONCLUSIONS: Percutaneous coronary sinus-based mitral annuloplasty reduces chronic IMR by reducing mitral annular A-P diameter and MVTa. This suggests the potential clinical application of a new nonsurgical therapeutic approach in patients with IMR. |
| | |
Authors:
|
Masao Daimon; Takahiro Shiota; A Marc Gillinov; Motoya Hayase; Marc Ruel; William E Cohn; Steven J Blacker; John R Liddicoat |
Related Documents
:
|
14063937 - Observations on the value of mitral commissurotomy: an analysis of long-term results. 6715707 - Validation of fourier amplitude ratio to quantitate valvular regurgitation. 18401477 - Mitral stenosis and cardiogenic shock from an obstructive abscess of the mitral annulus. 831407 - Systolic mitral flutter, an echocardiographic clue to the diagnosis of ruptured chordae... 9699887 - Medial thickness of coronary arteries as a correlate of atherosclerosis. 16133717 - The clinical variability of wallenberg's syndrome. the anatomical correlate of ipsilate... |
Publication Detail:
|
Type: Journal Article Date: 2005-04-25 |
Journal Detail:
|
Title: Circulation Volume: 111 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2005 May |
Date Detail:
|
Created Date: 2005-05-03 Completed Date: 2005-12-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
|
Languages: eng Pagination: 2183-9 Citation Subset: AIM; IM |
Affiliation:
|
Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiac Surgical Procedures Chronic Disease Echocardiography, Three-Dimensional Heart Catheterization Mitral Valve / surgery* Mitral Valve Insufficiency / surgery* Models, Animal Myocardial Ischemia* Sheep Surgical Procedures, Minimally Invasive |
| Comments/Corrections | |
Comment In:
|
Circulation. 2005 May 3;111(17):2154-6
[PMID:
15867192
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apol...
Next Document: Monitoring of bone marrow cell homing into the infarcted human myocardium.