| Percutaneous left atrial appendage transcatheter occlusion (PLAATO) for stroke prevention in atrial fibrillation: 2-year outcomes. | |
| | |
MedLine Citation:
|
PMID: 19726815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: In more than 90% of patients with atrial fibrillation (AF), stroke is due to thrombotic embolization from the left atrial appendage (LAA). Transcatheter occlusion with percutaneous left atrial appendage transcatheter occlusion (PLAATO), a self-expanding, membrane- covered spherical nitinol cage, is feasible and an alternative to anticoagulation therapy. METHODS: This was a single-center prospective registry study for verification of stroke risk reduction in patients with AF 2 years after PLAATO. RESULTS: Seventy-three patients with AF (permanent 65, paroxysmal 8) in whom anticoagulation therapy was contraindicated or rejected underwent transcatheter LAA occlusion with PLAATO. One patient died periprocedurally due to implant embolization, and 1 patient underwent open-heart surgery because of implant instability. The remaining 71 patients were followed for 24 months. In 52 patients a stable anchoring of the PLAATO device without migration or dislocation was documented by transesophageal echocardiography (TEE). No thrombotic deposition was found on the LA luminal surface of the device. Statistically, in our patient cohort, 7 strokes would have been expected without any treatment within 24 months. In fact, no strokes were reported. Ten out of 71 patients died during follow up: 6 in our hospital and 4 at home. None of them died from a stroke. CONCLUSIONS: Ninety-seven percent of AF patients were successfully treated with PLAATO. After mechanical LAA occlusion, the 2-year risk of stroke in AF patients is markedly reduced. Therefore, this therapeutic concept is a clear alternative for patients with AF and contraindications for oral anticoagulation. |
| | |
Authors:
|
Jai-Wun Park; Boris Leith?user; Ulrich Gerk; Martin Vrsansky; Friedrich Jung |
Related Documents
:
|
15009865 - Incidence of postdischarge symptomatic paroxysmal atrial fibrillation in patients who u... 7603405 - Incidence of childhood acute lymphoblastic leukemia (all) and population-based treatmen... 18307625 - The electrical substrate of vagal atrial fibrillation as assessed by the signal-average... 10509965 - The cox-maze iii procedure for atrial fibrillation associated with rheumatic mitral val... 17949555 - Serum mmp-2 and mmp-9 in patients with behçet's disease: do their higher levels correl... 4013265 - Carinal forceps biopsy via the fiberoptic bronchoscope in the routine staging of lung c... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of invasive cardiology Volume: 21 ISSN: 1557-2501 ISO Abbreviation: J Invasive Cardiol Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-09-03 Completed Date: 2010-01-28 Revised Date: 2010-03-29 |
Medline Journal Info:
|
Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 446-50 Citation Subset: IM |
Affiliation:
|
Hoyerswerda Hospital, 1st Medical Department, Cardiology, Angiology, Nephrology, Academic Teaching Hospital of the Technical University of Dresden, Hoyerswerda, Germany. jai-wunpark@t-online.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Alloys Angioplasty, Balloon / instrumentation, methods* Anticoagulants / contraindications Atrial Fibrillation / therapy* Female Follow-Up Studies Heart Catheterization / instrumentation, methods* Humans Male Middle Aged Prospective Studies Prostheses and Implants / adverse effects Registries Retrospective Studies Risk Factors Stroke / epidemiology, etiology, prevention & control* Thromboembolism / complications Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Alloys; 0/Anticoagulants; 52013-44-2/nitinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Causes of death in patients undergoing percutaneous coronary intervention with drug-eluting stents i...
Next Document: Effects of the number and interval of balloon inflations during primary PCI on the extent of myocard...