| Percutaneous isolated liver perfusion with occlusion balloons and a catheter-based stent-graft-like perfusion device: an experimental study in a porcine model. | |
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MedLine Citation:
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PMID: 20495978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the feasibility and safety of a novel percutaneous isolated liver perfusion (PILP) system in a porcine model. METHODS: The PILP catheter set, consisting of a portal vein and hepatic artery occlusion balloon and an hourglass-shaped vena cava stent-graft, was tested in six Dutch Landrace pigs. A veno-venous bypass between the distal portal vein and the right femoral vein, and isolated perfusion between the proximal portal vein and the hepatic veins were also created. Leak rate was determined using radioactivity measurement in the systemic circulation. Perfusion was then performed without (n = 2) or with cytotoxic drugs (n = 4). At the end of the procedure, all devices were retrieved and angiographic evaluation was performed of the involved vessel segments. RESULTS: In all pigs it was possible to insert, accurately position and retrieve all components of the PILP catheter set without angiographic signs of vessel-wall damage. Leakage rates to the systemic circulation were less than 7% over the course of the perfusion. CONCLUSION: In a porcine model, the PILP system can be safely and accurately positioned, and showed successful vascular isolation of the liver, with a leak rate to the systemic circulation of less than 7%. |
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Authors:
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Geert Maleux; Diethard Monbaliu; Chris Verslype; Christophe Casteleyn; Marc Van De Velde; Pieter Cornillie; Yvonne Hoogeveen; Eric Van Cutsem |
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Publication Detail:
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Type: Journal Article Date: 2010-05-22 |
Journal Detail:
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Title: European radiology Volume: 20 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 2372-80 Citation Subset: IM |
Affiliation:
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Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium. geert.maleux@uzleuven.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiography
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methods Animals Balloon Dilation* Catheterization Diagnostic Imaging / methods* Disease Models, Animal Equipment Design Hepatic Veins / pathology Liver / pathology* Perfusion / methods* Portal Vein / pathology Stainless Steel Stents Swine Vena Cava, Inferior / pathology |
| Chemical | |
Reg. No./Substance:
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12597-68-1/Stainless Steel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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