| Percutaneous intervention in peripheral artery disease improves calf muscle phosphocreatine recovery kinetics: a pilot study. | |
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MedLine Citation:
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PMID: 22363013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that percutaneous intervention in the affected lower extremity artery would improve calf muscle perfusion and cellular metabolism in patients with claudication and peripheral artery disease (PAD) as measured by magnetic resonance imaging (MRI) and spectroscopy (MRS). Ten patients with symptomatic PAD (mean ± SD: age 57 ± 9 years; ankle-brachial index (ABI) 0.62 ± 0.17; seven males) were studied 2 months before and 10 months after lower extremity percutaneous intervention. Calf muscle phosphocreatine recovery time constant (PCr) in the revascularized leg was measured by (31)P MRS immediately after symptom-limited exercise on a 1.5-T scanner. Calf muscle perfusion was measured using first-pass gadolinium-enhanced MRI at peak exercise. A 6-minute walk and treadmill test were performed. The PCr recovery time constant improved significantly following intervention (91 ± 33 s to 52 ± 34 s, p < 0.003). Rest ABI also improved (0.62 ± 0.17 to 0.93 ± 0.25, p < 0.003). There was no difference in MRI-measured tissue perfusion or exercise parameters, although the study was underpowered for these endpoints. In conclusion, in this pilot study, successful large vessel percutaneous intervention in patients with symptomatic claudication, results in improved ABI and calf muscle phosphocreatine recovery kinetics. |
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Authors:
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Amy M West; Justin D Anderson; Frederick H Epstein; Craig H Meyer; Klaus D Hagspiel; Stuart S Berr; Nancy L Harthun; Arthur L Weltman; Brian H Annex; Christopher M Kramer |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 17 ISSN: 1477-0377 ISO Abbreviation: Vasc Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-24 Completed Date: 2012-06-20 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 3-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Virginia Health System, University of Virginia, Charlottesville, VA 22908, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Ankle Brachial Index Exercise / physiology Exercise Test Female Humans Intermittent Claudication / surgery Leg / blood supply* Magnetic Resonance Angiography Magnetic Resonance Spectroscopy Male Middle Aged Muscle, Skeletal / blood supply*, metabolism Peripheral Arterial Disease / diagnosis, metabolism, surgery* Phosphocreatine / metabolism* Pilot Projects Regional Blood Flow Vascular Surgical Procedures / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL075792/HL/NHLBI NIH HHS; R01 HL075792/HL/NHLBI NIH HHS; R01 HL075792-07/HL/NHLBI NIH HHS; T32 EB003841/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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67-07-2/Phosphocreatine |
| Comments/Corrections | |
Comment In:
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Vasc Med. 2012 Feb;17(1):64-5
[PMID:
22363019
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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