Document Detail


Percutaneous intervention in peripheral artery disease improves calf muscle phosphocreatine recovery kinetics: a pilot study.
MedLine Citation:
PMID:  22363013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We hypothesized that percutaneous intervention in the affected lower extremity artery would improve calf muscle perfusion and cellular metabolism in patients with claudication and peripheral artery disease (PAD) as measured by magnetic resonance imaging (MRI) and spectroscopy (MRS). Ten patients with symptomatic PAD (mean ± SD: age 57 ± 9 years; ankle-brachial index (ABI) 0.62 ± 0.17; seven males) were studied 2 months before and 10 months after lower extremity percutaneous intervention. Calf muscle phosphocreatine recovery time constant (PCr) in the revascularized leg was measured by (31)P MRS immediately after symptom-limited exercise on a 1.5-T scanner. Calf muscle perfusion was measured using first-pass gadolinium-enhanced MRI at peak exercise. A 6-minute walk and treadmill test were performed. The PCr recovery time constant improved significantly following intervention (91 ± 33 s to 52 ± 34 s, p < 0.003). Rest ABI also improved (0.62 ± 0.17 to 0.93 ± 0.25, p < 0.003). There was no difference in MRI-measured tissue perfusion or exercise parameters, although the study was underpowered for these endpoints. In conclusion, in this pilot study, successful large vessel percutaneous intervention in patients with symptomatic claudication, results in improved ABI and calf muscle phosphocreatine recovery kinetics.
Authors:
Amy M West; Justin D Anderson; Frederick H Epstein; Craig H Meyer; Klaus D Hagspiel; Stuart S Berr; Nancy L Harthun; Arthur L Weltman; Brian H Annex; Christopher M Kramer
Related Documents :
7758223 - Measurement of serum lipid peroxidation during exercise using three different methods: ...
12581793 - Dietary vitamin e and physical exercise: ii. antioxidant status and lipofuscin-like sub...
1951723 - Neuropeptide y and 3,4-dihydroxyphenylglycol effluxes from artery are oxygen sensitive.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  17     ISSN:  1477-0377     ISO Abbreviation:  Vasc Med     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-20     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Ankle Brachial Index
Exercise / physiology
Exercise Test
Female
Humans
Intermittent Claudication / surgery
Leg / blood supply*
Magnetic Resonance Angiography
Magnetic Resonance Spectroscopy
Male
Middle Aged
Muscle, Skeletal / blood supply*,  metabolism
Peripheral Arterial Disease / diagnosis,  metabolism,  surgery*
Phosphocreatine / metabolism*
Pilot Projects
Regional Blood Flow
Vascular Surgical Procedures / methods*
Grant Support
ID/Acronym/Agency:
R01 HL075792/HL/NHLBI NIH HHS; R01 HL075792/HL/NHLBI NIH HHS; R01 HL075792-07/HL/NHLBI NIH HHS; T32 EB003841/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
020IUV4N33/Phosphocreatine
Comments/Corrections
Comment In:
Vasc Med. 2012 Feb;17(1):64-5   [PMID:  22363019 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The cellular basis of GABA(B)-mediated interhemispheric inhibition.
Next Document:  Progression of asymptomatic peripheral artery disease over 1 year.