Document Detail

Percutaneous embolization on hereditary hemorrhagic telangiectasia patients with severe epistaxis.
MedLine Citation:
PMID:  19593974     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the results of embolization in patients with hereditary hemorrhagic telangiectasia (HHT) because of severe epistaxis. METHODS: All HHT patients who underwent an embolization (between 1992 and 2006) were asked to participate in this retrospective study. Twelve patients who had in total 19 embolization procedures were interviewed. A questionnaire was used assessing the frequency, severity, duration of epistaxis and their Impact on Lifestyle (IoL). Haemoglobin values were collected from the patients' records. Embolization of the pathologically enhancing lesions was performed using PVA particles. RESULTS: The direct effect of the embolization is very good in 95% of patients. The Impact factor (daily frequency x severity) of epistaxis improved in the first month (p = 0.000) and one year after embolization (p = 0.009). Eleven embolizations (61%) were still associated with significant improvement. There was a reduction in the duration of epistaxis by 16 minutes per day one month after embolization (p = 0.005). However, this reduction was not found one year after embolization. Mean haemoglobin rose significantly after 1 year by an average of 0.8 mmol/l (p = 0.045). Impact on Lifestyle improved in 68% of the procedures and was unchanged in 32%. CONCLUSION: Embolizations remain a therapeutic option in experienced hands. The indication should be made carefully, because of possible (major) complications.
S J Braak; C A de Witt; F J M Disch; T Th C Overtoom; J J Westermann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rhinology     Volume:  47     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-14     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  166-71     Citation Subset:  IM    
Department of Radiology, St Antonius Hospital, Nieuwegein, The Netherlands.
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MeSH Terms
Embolization, Therapeutic / methods*
Epistaxis / etiology*,  therapy*
Middle Aged
Retrospective Studies
Severity of Illness Index
Statistics, Nonparametric
Telangiectasia, Hereditary Hemorrhagic / complications*
Treatment Outcome

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