Document Detail

Percutaneous coronary interventions affect concentrations of interleukin 6 and its soluble receptors in coronary sinus blood in patients with stable angina.
MedLine Citation:
PMID:  19508977     Owner:  NLM     Status:  MEDLINE    
Coronary stenting may create local inflammatory reaction. Interleukin 6 effects depend on the presence of soluble receptors (sIL-6R and sgp130) that facilitate or impede interleukin 6 signal transduction. Concentrations of interleukin 6 and its soluble receptors were assessed in aorta and coronary sinus after stenting in optimally treated stable angina patients scheduled for elective stenting. Baseline levels of interleukin 6 and its soluble receptors in patients did not differ from healthy controls. Initial levels of sIL-6R in aorta were significantly higher than in coronary sinus but this difference disappeared after intervention. Stenting caused interleukin 6 concentration increase to a similar extent both in coronary sinus and in aorta. Moreover, there was significantly higher sgp130 concentration in coronary sinus than in aorta. Coronary intervention increases concentration of interleukin 6 in patients with stable angina. It affects the cardiac level of interleukin 6 soluble receptors what may influence the local inflammatory reaction.
Karol A Kaminski; Anna Kozieradzka; Tomasz Bonda; Maciej Banach; Marcin Kozuch; Izabela Wojtkowska; Slawomir Dobrzycki; Pawel Kralisz; Konrad Nowak; Przemyslaw Prokopczuk; Dimitri P Mikhailidis; Wlodzimierz J Musial
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-08
Journal Detail:
Title:  Angiology     Volume:  60     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:    2009 Jun-Jul
Date Detail:
Created Date:  2009-07-22     Completed Date:  2009-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  322-8     Citation Subset:  IM    
Medical University of Bialystok, Department of Cardiology, Bialystok, Poland.
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MeSH Terms
Angina Pectoris / immunology*,  therapy*
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Sinus
Cytokine Receptor gp130 / blood*
Interleukin-6 / blood*
Middle Aged
Myocardial Ischemia / immunology*,  therapy*
Reference Values
Signal Transduction / physiology
Reg. No./Substance:
0/IL6ST protein, human; 0/Interleukin-6; 133483-10-0/Cytokine Receptor gp130

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