Document Detail

Percutaneous coronary intervention increases microvascular resistance in patients with non-ST-elevation acute coronary syndrome.
MedLine Citation:
PMID:  23410633     Owner:  NLM     Status:  MEDLINE    
AIMS: In the acute coronary syndrome setting, the interaction between epicardial coronary artery stenosis and microcirculation subtended by the culprit vessel is poorly understood. The purpose of the present study was to assess the immediate impact of percutaneous coronary intervention (PCI) on microvascular resistance (MR) in patients with non-ST-elevation myocardial infarction (NSTEMI).
METHODS AND RESULTS: Thirty-eight patients undergoing PCI for NSTEMI were recruited consecutively. Culprit lesions were stented over a Doppler and pressure-sensor-equipped guidewire. In the presence of epicardial stenosis, MR was calculated by taking collateral flow, as measured by the coronary wedge pressure, into consideration. After removal of epicardial stenosis, MR was calculated simply as distal coronary pressure divided by average peak velocity. When collateral flow was incorporated into the calculation, MR increased significantly from 1.70 ± 0.76 to 2.05 ± 0.72 (p=0.001) after PCI in the whole population. Periprocedural changes (Δ) in absolute values of MR and troponin T correlated significantly (r=0.629, p=0.0001). In patients who developed periprocedural myocardial infarction, MR increased significantly after PCI (1.48 ± 0.73 versus 2.28 ± 0.71, p<0.001). Nevertheless, removal of the epicardial lesion did not change MR in patients without periprocedural MI (1.91±0.73 versus 1.81±0.67, p=0.1).
CONCLUSIONS: When collateral flow is accounted for, removal of epicardial stenosis increases MR in patients with NSTEMI undergoing PCI.
Cansu Akdeniz; Sabahattin Umman; Yilmaz Nisanci; Berrin Umman; Zehra Bugra; Emre K Aslanger; Abdullah Kaplan; Akar Yilmaz; Erhan Teker; Göksel Güz; Nihat Polat; Murat Sezer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  9     ISSN:  1969-6213     ISO Abbreviation:  EuroIntervention     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-24     Completed Date:  2014-03-17     Revised Date:  2014-05-29    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  France    
Other Details:
Languages:  eng     Pagination:  228-34     Citation Subset:  IM    
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MeSH Terms
Acute Coronary Syndrome / blood,  diagnosis,  physiopathology,  therapy*
Biological Markers / blood
Blood Flow Velocity
Blood Pressure
Chi-Square Distribution
Collateral Circulation
Coronary Circulation*
Coronary Stenosis / blood,  diagnosis,  physiopathology,  therapy*
Echocardiography, Doppler
Linear Models
Myocardial Infarction / blood,  diagnosis,  physiopathology,  therapy*
Myocardium / metabolism,  pathology
Percutaneous Coronary Intervention / adverse effects*
Predictive Value of Tests
Risk Factors
Treatment Outcome
Troponin T / blood
Vascular Resistance*
Reg. No./Substance:
0/Biological Markers; 0/Troponin T
Comment In:
EuroIntervention. 2014 Apr;9(12):1485-8   [PMID:  24755391 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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