| Percutaneous coronary intervention in a patient with factor XI deficiency. | |
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MedLine Citation:
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PMID: 19726832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Factor XI deficiency is a rare coagulopathy occurring primarily in Ashkenazi Jews, and is associated with bleeding diathesis. This disorder complicates management during invasive procedures and poses a challenge during the performance of percutaneous coronary intervention (PCI). This situation is unique because there is a contradictory need to achieve procedural anticoagulation while minimizing the risk of bleeding. There is only one case report on the management of anticoagulation during PCI in patients with Factor XI deficiency advocating the avoidance of anticoagulation during the procedure. There is some evidence to suggest that severe Factor XI deficiency may be protective against ischemic stroke, but not against myocardial infarction. It appears, therefore, that the prolonged aPTT observed in these patients might not reflect a complete anticoagulant state and cannot be relied upon to provide procedural anticoagulation during PCI. We report our experience which suggests that PCI in these patients may be performed safely in the usual manner following the administration of plasma. |
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Authors:
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Avi Shimony; Etai Levi; Doron Zahger |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of invasive cardiology Volume: 21 ISSN: 1557-2501 ISO Abbreviation: J Invasive Cardiol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-03 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: E178-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel. ashimony@bgu.ac.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Angioplasty, Transluminal, Percutaneous Coronary / methods* Aspirin / therapeutic use Factor XI Deficiency / complications* Humans Male Myocardial Infarction / therapy* Platelet Aggregation Inhibitors / therapeutic use Stents Ticlopidine / analogs & derivatives, therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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