Document Detail

Percutaneous closure of atrial septal defects: echocardiographic and functional results in patients older than 60 years.
MedLine Citation:
PMID:  20031700     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Percutaneous closure of atrial septal defects is well established in children and adults and has been found to improve symptoms and positively influence right-heart remodeling. The aim of this study was to evaluate the efficacy and long-term outcome in adult patients older than 60 years. METHODS AND RESULTS: The study population comprised 96 patients in the age group of 60 to 84 years. Percutaneous closure was performed effectively in all patients. Functional capacity according to New York Heart Association functional class and peak oxygen uptake (VO(2)max) in the cardiopulmonary exercise testing improved significantly after atrial septal defects closure, especially in patients with a pulmonary-to-systemic flow ratio >2. Echocardiographic measurements of the right ventricular end-diastolic diameter showed a significant decrease. No device-associated complications were observed, but in 16 patients, paroxysmal atrial fibrillation occurred after device implantation. CONCLUSIONS: Percutaneous atrial septal defects closure can be performed safely and with minimal risk even in elderly patients. They profit in terms of symptom reduction, improvement of exercise capacity, and right-heart remodeling.
Smita Jategaonkar; Werner Scholtz; Henning Schmidt; Dieter Horstkotte
Publication Detail:
Type:  Journal Article     Date:  2009-02-20
Journal Detail:
Title:  Circulation. Cardiovascular interventions     Volume:  2     ISSN:  1941-7632     ISO Abbreviation:  Circ Cardiovasc Interv     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101499602     Medline TA:  Circ Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Georgstrasse 11, Bad Oeynhausen, Germany.
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MeSH Terms
Age Factors
Aged, 80 and over
Atrial Fibrillation / etiology
Echocardiography, Transesophageal*
Exercise Test
Exercise Tolerance
Heart Catheterization* / adverse effects,  instrumentation
Heart Septal Defects, Atrial / physiopathology,  therapy*,  ultrasonography
Middle Aged
Oxygen Consumption
Patient Selection
Recovery of Function
Risk Assessment
Septal Occluder Device
Time Factors
Treatment Outcome
Ventricular Remodeling
Comment In:
Circ Cardiovasc Interv. 2009 Apr;2(2):83-4   [PMID:  20031699 ]

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