| Percutaneous absorption of sulconazole nitrate in humans. | |
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MedLine Citation:
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PMID: 3171926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The percutaneous absorption of 1% sulconazole nitrate in a cream formulation containing 3H-labeled drug has been studied in seven human subjects. Two applications of 4.5 g each were made to 450 cm2 of abdominal skin at 0 and 12 h, and the site was washed at 24 h. The application site was subsequently washed at 24-h intervals for 3 consecutive days, and 6.7% of the dose was recovered in the urine and 2.0% in the feces following a 7-d collection period. Radioactivity was detectable in the plasma from 8-96 h, with a peak occurring at 24 h, and could also be recovered in the skin wash up to 96 h after application. Total percutaneous absorption of sulconazole was estimated to be 8.7-11.3% of the applied dose, considerably more than that previously reported for other imidazole drugs. |
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Authors:
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T J Franz; P Lehman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 77 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-11-07 Completed Date: 1988-11-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 489-91 Citation Subset: IM |
Affiliation:
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Dermatopharmacology Laboratory, University of Washington, School of Medicine, Seattle 98195. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Antifungal Agents / blood, pharmacokinetics*, urine Feces / analysis Humans Imidazoles / blood, pharmacokinetics*, urine Macaca mulatta Male Skin Absorption* |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Imidazoles; 61318-90-9/sulconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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