Document Detail

Percutaneous absorption kinetics of topical metronidazole formulations in vitro in the human cadaver skin model.
MedLine Citation:
PMID:  17565913     Owner:  NLM     Status:  MEDLINE    
Topical formulations containing identical active agents are available in various vehicles and concentrations, which may affect percutaneous absorption. This study was undertaken to evaluate the in vitro percutaneous absorption pharmacokinetics of metronidazole in different vehicles and concentrations as the active agent in 6 topical formulations. Formulations were applied to sections from 3 cadaver skin donors, and percutaneous absorption of metronidazole was measured over a 48-h test period through the finite dose technique and the use of Franz diffusion cells. Metronidazole penetrates into and through human cadaver skin. Data show the general ranking of delivery of similar concentrations of metronidazole according to vehicle as cream > lotion > gel. The 48-h penetration of metronidazole in the human cadaver skin model was greatest with cream formulations and lowest with gel formulations. These results reveal the importance of the vehicle selected for penetration of metronidazole into the skin. The relevant target zone in rosacea is the dermis because this is the area where inflammation takes place. Additional studies are warranted to examine absorption of metronidazole into the relevant target zone and the correlation of absorption with efficacy.
Boni E Elewski
Related Documents :
12520633 - Lack of bioequivalence of gatifloxacin when coadministered with calcium-fortified orang...
3315273 - Food interactions with once-a-day theophylline preparations: a review.
10849273 - Adenylate kinase amplification of atp bioluminescence for hygiene monitoring in the foo...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in therapy     Volume:  24     ISSN:  0741-238X     ISO Abbreviation:  Adv Ther     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-06-13     Completed Date:  2007-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-46     Citation Subset:  T    
Department of Dermatology, University of Alabama School of Medicine, Birmingham, AL 35294-0009, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Infective Agents / pharmacokinetics*
Chemistry, Pharmaceutical
Dosage Forms
Dose-Response Relationship, Drug
Metronidazole / pharmacokinetics*
Middle Aged
Skin Absorption / drug effects*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Dosage Forms; 0/Gels; 0/Vehicles; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Short-term ethanol administration does not change the total pyramidal neuron number of the rat hippo...
Next Document:  Effects of ropivacaine on pain after laparoscopic cholecystectomy: a prospective, randomized study.